SMARCE1 and SPAG5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SMARCE1	SPAG5
Description		SWI/SNF related BAF chromatin remodeling complex subunit E1	sperm associated antigen 5
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Chromosome, Centromeric Region Kinetochore Spindle Pole Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Midbody Centriolar Satellite Ciliary Rootlet Microtubule Plus-end Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding	Protein Binding Microtubule Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Neurogenesis Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Mitotic Sister Chromatid Segregation Spindle Organization Chromosome Segregation Positive Regulation Of Intracellular Transport Establishment Of Spindle Orientation Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Centrosome Regulation Of Metaphase Plate Congression Positive Regulation Of Spindle Assembly
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 30929738 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		94 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEBPA CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ERG ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 HUNK IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OGT OIP5 PGR PSMC6 RALBP1 RARB RCOR1 RELB RINT1 RSPH1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TIAM1 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52	59 interacting genes: AIRIM AMOTL2 ARNT2 ATN1 BARD1 CCDC33 CCHCR1 CDC20B CDK1 CENPH CHCHD3 DCLRE1B DCX EIF4E2 EIF4ENIF1 ENKD1 FBXO28 FMR1 GEM GOLGA8EP GOLGA8F HAUS1 IGFN1 IQCE KANSL1 KRT3 KRT75 LGALS14 LINGO1 MID1 MID2 NEBL NLGN3 ODF1 ORC6 PIMREG PKN1 PLK4 POLR2L POM121 RBM41 SH2D4A SHANK3 SMARCA2 SMARCE1 SNAP47 SNAPIN SPAG5-AS1 TSC1 TSHZ3 TTC23 ZC2HC1C ZFC3H1 ZFYVE26 ZGPAT ZMAT2 ZNF385C ZNF572 ZNF688
Entrez ID		6605	10615
HPRD ID		04382	10246
Ensembl ID		ENSG00000073584	ENSG00000076382
Uniprot IDs		Q969G3	Q96R06
PDB IDs		6LTH 6LTJ 7CYU 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Receptor-mediated Signaling Pathway Morphogenesis Of An Epithelium Cytoskeleton Tissue Morphogenesis Estrogen Response Element Binding Chromatin Structural Molecule Activity Protein Binding Intracellular Receptor Signaling Pathway Cytoskeleton Organization Organelle Organization Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Steroid Binding Nuclear Receptor Activity Supramolecular Fiber Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Epithelial Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Sin3-type Complex Estrogen Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Cytosol Positive Regulation Of RNA Metabolic Process Epidermis Development Cell Differentiation DNA-binding Transcription Factor Activity Protein-containing Complex Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Developmental Process Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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