SMARCE1 and ARID2

Number of citations of the paper that reports this interaction (PubMedID 15985610)
29

Data Source:
HPRD (in vivo)

		SMARCE1	ARID2
Description		SWI/SNF related BAF chromatin remodeling complex subunit E1	AT-rich interaction domain 2
Image
GO Annotations	Cellular Component	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex	Kinetochore Chromatin Nucleus Nucleoplasm Plasma Membrane Nuclear Matrix SWI/SNF Complex RSC-type Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Neurogenesis Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Heart Morphogenesis Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Cell Migration Homeostatic Process Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Embryonic Organ Development Cardiac Muscle Cell Proliferation Coronary Artery Morphogenesis Regulation Of G0 To G1 Transition Circulatory System Development Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Formation of the polybromo-BAF (pBAF) complex
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 30929738 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Triglyceride levels in HIV infection ( 33109212)	Chronotype ( 30696823) Fish- and plant-related diet ( 32066663) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hippocampal atrophy ( 19668339) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Morning person ( 30696823) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triglyceride levels ( 32203549) Triglycerides ( 30275531)
Interacting Genes		94 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEBPA CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ERG ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 HUNK IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OGT OIP5 PGR PSMC6 RALBP1 RARB RCOR1 RELB RINT1 RSPH1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TIAM1 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52	8 interacting genes: CCNA1 MSRA NFYC SMARCA4 SMARCE1 SUMO2 TSC22D2 YAP1
Entrez ID		6605	196528
HPRD ID		04382	16505
Ensembl ID		ENSG00000073584	ENSG00000189079
Uniprot IDs		Q969G3	F8WCU9 Q68CP9
PDB IDs		6LTH 6LTJ 7CYU 7VDV 7Y8R	7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Receptor-mediated Signaling Pathway Morphogenesis Of An Epithelium Cytoskeleton Tissue Morphogenesis Estrogen Response Element Binding Chromatin Structural Molecule Activity Protein Binding Intracellular Receptor Signaling Pathway Cytoskeleton Organization Organelle Organization Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Steroid Binding Nuclear Receptor Activity Supramolecular Fiber Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Epithelial Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Sin3-type Complex Estrogen Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Cytosol Positive Regulation Of RNA Metabolic Process Epidermis Development Cell Differentiation DNA-binding Transcription Factor Activity Protein-containing Complex Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Developmental Process Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process	Positive Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Population Maintenance Regulation Of Myoblast Differentiation BBAF Complex NBAF Complex RSC-type Complex NpBAF Complex Nucleosome Disassembly Protein-DNA Complex Disassembly Negative Regulation Of Stem Cell Differentiation Regulation Of Nucleotide-excision Repair SWI/SNF Complex Regulation Of G0 To G1 Transition Nucleosomal DNA Binding L-methionine:thioredoxin-disulfide S-oxidoreductase Activity Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Coactivator Activity Positive Regulation Of Myoblast Differentiation Mesenchyme Development Enterocyte Differentiation Anterior Visceral Endoderm Cell Migration Negative Regulation Of Cardiac Muscle Cell Myoblast Differentiation Polarized Secretion Of Basement Membrane Proteins In Epithelium Cell Trailing Edge Phosphatidylserine Exposure On Blood Platelet Regulation Of Wnt Signaling Pathway Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Stem Cell Differentiation Establishment Of Bipolar Cell Polarity Involved In Cell Morphogenesis Focal Adhesion Disassembly Activation Of Blood Coagulation Via Clotting Cascade Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Double-strand Break Repair Regulation Of Sister Chromatid Segregation Positive Regulation Of Glucose Mediated Signaling Pathway Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Cyclin A2-CDK2 Complex TEAD-YAP Complex Extracellular Matrix Constituent Secretion Tear Secretion
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