WWTR1 and YWHAZ

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		WWTR1	YWHAZ
Gene Name		WW domain containing transcription regulator 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Focal Adhesion Postsynaptic Density Cytoplasmic Vesicle Membrane Cell Leading Edge Melanosome Mast Cell Granule Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Protein Binding Transcription Factor Binding Protein Kinase Binding Protein Domain Specific Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Cilium Morphogenesis Regulation Of SMAD Protein Import Into Nucleus Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	Histamine Secretion By Mast Cell Protein Targeting To Mitochondrion Apoptotic Process Signal Transduction Blood Coagulation Gene Expression Platelet Activation Response To Drug Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization Membrane Organization Golgi Reassembly Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Metabolism of lipids and lipoproteins SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by Hippo Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) SMAD4 MH2 Domain Mutants in Cancer	Translocation of GLUT4 to the plasma membrane Activation of BH3-only proteins Signaling by Wnt deactivation of the beta-catenin transactivating complex Rap1 signalling RNF mutants show enhanced WNT signaling and proliferation Programmed Cell Death XAV939 inhibits tankyrase, stabilizing AXIN Intrinsic Pathway for Apoptosis Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytokine Signaling in Immune system Activation of BAD and translocation to mitochondria Signaling by Interleukins TCF dependent signaling in response to WNT KSRP destabilizes mRNA GP1b-IX-V activation signalling Signaling by WNT in cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs
Diseases
GWAS		Preeclampsia ( 23551011)	Attention deficit hyperactivity disorder and conduct disorder ( 18951430)
Protein-Protein Interactions		11 interactors: LATS1 NKX2-1 PAX3 PPP1CA RUNX1 SLC9A3R2 TEAD3 TEAD4 YWHAE YWHAG YWHAZ	191 interactors: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARAF ARHGEF2 ATP5A1 ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CFL1 CGNL1 CLIC4 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EPB41L1 EPB41L2 EPB41L3 EXO1 FAM13B FAM53C FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 HDAC4 HDAC9 HIST1H3A HIVEP2 HMGN1 HSPA1A HSPA1B IGF1R IL9R ING1 INPP5A IRS1 IRS2 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIAA1377 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LCP2 LIMK1 LRMP LYST MADD MAP2K5 MAP3K2 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PRDX2 PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RFWD2 RGS3 RIN1 RMDN3 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNX24 SORBS2 SQSTM1 SSFA2 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YWHAE ZAK ZNF839
Entrez ID		25937	7534
HPRD ID		09580	03183
Ensembl ID		ENSG00000018408	ENSG00000164924
Uniprot IDs		Q9GZV5	D0PNI1 P63104
PDB IDs			1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL
Enriched GO Terms of Interacting Partners?		Hippo Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Maintenance Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Mitochondrion Organization G2/M Transition Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter Regulation Of Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Epithelium Development Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway System Development Organ Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Intracellular Transport Tissue Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Multicellular Organismal Development Cell Differentiation Positive Regulation Of Transport Positive Regulation Of Stem Cell Differentiation Cell Fate Commitment Neural Nucleus Development Anatomical Structure Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization Positive Regulation Of Gene Expression Generation Of Neurons Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hippocampus Development Regulation Of Cellular Process Neurogenesis	Intracellular Signal Transduction Cell Communication Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Signaling Regulation Of Cellular Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Protein Metabolic Process Response To Stimulus Signal Transduction Regulation Of Kinase Activity Regulation Of Cellular Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Protein Phosphorylation Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Protein Kinase Activity Response To Stress Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Signal Transduction Protein Phosphorylation Neurotrophin Signaling Pathway Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Cellular Protein Modification Process Response To Organic Substance Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Cellular Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Cell Surface Receptor Signaling Pathway Regulation Of Cell Death Regulation Of MAPK Cascade Apoptotic Process Cell Death Death Programmed Cell Death Positive Regulation Of Protein Modification Process Phosphate-containing Compound Metabolic Process Regulation Of Apoptotic Process Innate Immune Response Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization
Tagcloud ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl wwox wwp1 yap1 yes	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Difference) ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl wwox wwp1 yap1 yes	actb arfgap2 arl1 bestkeeper bmi1 casc3 cynomolgus ddx3x gapdh genorm lists monkey morf4 mrfap1 normalization normfinder ormdl1 prerequisite reference ribosylation rps19 rsl24d1 sar1a traditionally transcriptome usp22 vitally zc3h11a zranb2
Tagcloud (Intersection) ?