WWTR1 and PAX3

Number of citations of the paper that reports this interaction (PubMedID 16300735)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		WWTR1	PAX3
Description		WW domain containing transcription regulator 1	paired box 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Nuclear Body Anchoring Junction	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Heart Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly SMAD Protein Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Muscle Organ Development Sensory Perception Of Sound Anatomical Structure Morphogenesis Animal Organ Morphogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription	HATs acetylate histones Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases			Alveolar rhabdomyosarcoma Waardenburg syndrome (WS) Craniofacial-deafness-hand syndrome
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011) Triglyceride levels ( 34074324)	Adolescent idiopathic scoliosis ( 26394188) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132) Facial morphology ( 22341974 31763980) Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Information processing speed ( 25869804) Male-pattern baldness ( 28196072) middle facial morphology traits (quantitative measurement) ( 27193062) Monobrow ( 27182965) Monobrow thickness ( 26926045) Nose size ( 27182965) Vitamin D levels ( 25208829) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		21 interacting genes: BTRC C1orf74 DAPK1 IL16 LATS2 MFHAS1 NHERF2 NKX2-1 PAX3 PRRG2 PRRG4 RTN4IP1 RUNX1 SUMO3 TCP11L1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAZ	18 interacting genes: CIB1 DAXX FZR1 HDAC10 IPO13 KRTAP6-2 KRTAP8-1 MEOX1 MEOX2 MITF MSX1 POU3F2 RAD23B SOX10 SOX8 TAF1 TBP WWTR1
Entrez ID		25937	5077
HPRD ID		09580	09421
Ensembl ID		ENSG00000018408	ENSG00000135903
Uniprot IDs		Q9GZV5	P23760
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX 8R0Z	3CMY
Enriched GO Terms of Interacting Partners?		Hippo Signaling Intracellular Signal Transduction Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Transcription Regulator Complex Positive Regulation Of Circadian Rhythm Positive Regulation Of Hippo Signaling Negative Regulation Of Immune System Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex Sequence-specific DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Somite Specification Positive Regulation Of Biosynthetic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of DNA-templated Transcription RNA Polymerase II General Transcription Initiation Factor Binding Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Activity P53 Binding Positive Regulation Of DNA-templated Transcription Initiation DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Enteric Nervous System Development Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Initiation Nucleoplasm Regulation Of Gene Expression DNA Binding Regulation Of Macromolecule Biosynthetic Process Segment Specification Somite Development Regulation Of Cell Population Proliferation Transcription Cis-regulatory Region Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Melanocyte Differentiation
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