WWTR1 and NKX2-1

Number of citations of the paper that reports this interaction (PMID 14970209)
33

Data Source:
HPRD (in vivo, in vitro)

		WWTR1	NKX2-1
Gene Name		WW domain containing transcription regulator 1	NK2 homeobox 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol	Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	Core Promoter Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Enzyme Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Differentiation Negative Regulation Of Protein Phosphorylation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Protein Kinase Activity Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Catenin Import Into Nucleus Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Mesenchymal Cell Differentiation Cilium Morphogenesis Regulation Of SMAD Protein Import Into Nucleus Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Neuron Migration Transcription From RNA Polymerase II Promoter Phospholipid Metabolic Process Axon Guidance Brain Development Endoderm Development Locomotory Behavior Response To Hormone Positive Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Globus Pallidus Development Hippocampus Development Cerebral Cortex Cell Migration Forebrain Dorsal/ventral Pattern Formation Forebrain Neuron Fate Commitment Cerebral Cortex GABAergic Interneuron Differentiation Pituitary Gland Development Lung Development Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Forebrain Development Developmental Induction Leydig Cell Differentiation Positive Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Anatomical Structure Formation Involved In Morphogenesis Oligodendrocyte Differentiation Lung Saccule Development Epithelial Tube Branching Involved In Lung Morphogenesis Clara Cell Differentiation Type II Pneumocyte Differentiation
Pathways		Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Metabolism of lipids and lipoproteins SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Generic Transcription Pathway TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by Hippo Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Preeclampsia ( 23551011)	Height ( 18391950) Menarche (age at onset) ( 23667675) Thyroid cancer ( 19198613)
Protein-Protein Interactions		11 interactors: LATS1 NKX2-1 PAX3 PPP1CA RUNX1 SLC9A3R2 TEAD3 TEAD4 YWHAE YWHAG YWHAZ	14 interactors: CALR CREBBP GATA6 HIPK2 MAPK1 NCOA1 NCOA2 NCOA3 PAX8 PTRF RARA RELA TDG WWTR1
Entrez ID		25937	7080
HPRD ID		09580	02798
Ensembl ID		ENSG00000018408	ENSG00000136352
Uniprot IDs		Q9GZV5	P43699
PDB IDs
Enriched GO Terms of Interacting Partners?		Hippo Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Stem Cell Maintenance Positive Regulation Of Mitochondrion Organization Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Mitochondrion Organization G2/M Transition Of Mitotic Cell Cycle Transcription From RNA Polymerase II Promoter Regulation Of Stem Cell Maintenance Positive Regulation Of Transcription From RNA Polymerase II Promoter Morphogenesis Of An Epithelium Epithelium Development Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway System Development Organ Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Intracellular Transport Tissue Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Multicellular Organismal Development Cell Differentiation Positive Regulation Of Transport Positive Regulation Of Stem Cell Differentiation Cell Fate Commitment Neural Nucleus Development Anatomical Structure Development Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Protein Localization Positive Regulation Of Gene Expression Generation Of Neurons Regulation Of Cell Differentiation Response To Organic Substance Regulation Of Cell Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Hippocampus Development Regulation Of Cellular Process Neurogenesis	Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Regulation Of Nitrogen Compound Metabolic Process Response To Hormone Intracellular Receptor Signaling Pathway Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Embryo Development Gland Development Response To Organic Substance Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Organ Morphogenesis Embryonic Morphogenesis Nitrogen Compound Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Tissue Development Anatomical Structure Morphogenesis Response To Estrogen Regulation Of Metabolic Process Response To Steroid Hormone Positive Regulation Of Cell Proliferation
Tagcloud ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl wwox wwp1 yap1 yes
Tagcloud (Difference) ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a sgsm3 tumorigenic unchanged wbp2 wbp2nl wwox wwp1 yap1 yes
Tagcloud (Intersection) ?