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WWTR1
Gene Name
WW domain containing transcription regulator 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Transcription Factor Complex
Cytoplasm
Cytosol
Molecular Function
Transcription Coactivator Activity
Transcription Corepressor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Osteoblast Differentiation
Negative Regulation Of Protein Phosphorylation
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Protein Kinase Activity
Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Protein Ubiquitination
Stem Cell Division
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Glomerulus Development
Multicellular Organism Growth
Hippo Signaling
Negative Regulation Of Catenin Import Into Nucleus
Negative Regulation Of Fat Cell Differentiation
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Mesenchymal Cell Differentiation
Cilium Morphogenesis
Regulation Of SMAD Protein Import Into Nucleus
Kidney Morphogenesis
Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Loss of Function of TGFBR2 in Cancer
PPARA activates gene expression
Metabolism of lipids and lipoproteins
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Generic Transcription Pathway
TGFBR2 MSI Frameshift Mutants in Cancer
Fatty acid, triacylglycerol, and ketone body metabolism
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by Hippo
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Preeclampsia (
23551011
)
Protein-protein Interactions
11 interactors:
LATS1
NKX2-1
PAX3
PPP1CA
RUNX1
SLC9A3R2
TEAD3
TEAD4
YWHAE
YWHAG
YWHAZ
Entrez ID
25937
HPRD ID
09580
Ensembl ID
ENSG00000018408
Uniprot IDs
Q9GZV5
PDB IDs
Enriched GO Terms of Interacting Partners
?
Hippo Signaling
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Positive Regulation Of Apoptotic Signaling Pathway
Positive Regulation Of Stem Cell Maintenance
Positive Regulation Of Mitochondrion Organization
Regulation Of Signal Transduction
Regulation Of Signaling
Regulation Of Mitochondrion Organization
G2/M Transition Of Mitotic Cell Cycle
Transcription From RNA Polymerase II Promoter
Regulation Of Stem Cell Maintenance
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Morphogenesis Of An Epithelium
Epithelium Development
Intracellular Signal Transduction
Intrinsic Apoptotic Signaling Pathway
System Development
Organ Development
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cell Death
Positive Regulation Of Intracellular Transport
Tissue Morphogenesis
Regulation Of Establishment Of Protein Localization
Positive Regulation Of Transcription, DNA-templated
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Multicellular Organismal Development
Cell Differentiation
Positive Regulation Of Transport
Positive Regulation Of Stem Cell Differentiation
Cell Fate Commitment
Neural Nucleus Development
Anatomical Structure Development
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Localization
Positive Regulation Of Gene Expression
Generation Of Neurons
Regulation Of Cell Differentiation
Response To Organic Substance
Regulation Of Cell Development
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Hippocampus Development
Regulation Of Cellular Process
Neurogenesis
Tagcloud
?
athanogene
bag3
bcl2
cancerous
developmentally
e3
fnbp4
formin
guanylatekinase
ligase
magi1
modulator
nedd4
oncogene
oncogenic
oxidoreductase
pdz
property
rab2a
sgsm3
tumorigenic
unchanged
wbp2
wbp2nl
wwox
wwp1
yap1
yes