WWTR1 and TEAD2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		WWTR1	TEAD2
Description		WW domain containing transcription regulator 1	TEA domain transcription factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Nuclear Body Anchoring Junction	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytosol TEAD-YAP Complex
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Disordered Domain Specific Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Tissue Homeostasis Heart Process Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Stem Cell Division SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Glomerulus Development Multicellular Organism Growth Hippo Signaling Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal Cell Differentiation Cilium Assembly SMAD Protein Signal Transduction Regulation Of Canonical Wnt Signaling Pathway Kidney Morphogenesis Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Localization To Nucleus	Vasculogenesis Neural Tube Closure Embryonic Heart Tube Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Notochord Development Hippo Signaling Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Development Lateral Mesoderm Development Embryonic Organ Development Mesenchyme Development Protein-containing Complex Assembly Cellular Response To Retinoic Acid Regulation Of Stem Cell Differentiation
Pathways		Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression YAP1- and WWTR1 (TAZ)-stimulated gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Physiological factors RUNX2 regulates osteoblast differentiation RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination Regulation of PD-L1(CD274) transcription	YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription Formation of axial mesoderm Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Height ( 31562340) Polycystic ovary syndrome ( 32289280) Preeclampsia ( 23551011) Triglyceride levels ( 34074324)
Interacting Genes		21 interacting genes: BTRC C1orf74 DAPK1 IL16 LATS2 MFHAS1 NHERF2 NKX2-1 PAX3 PRRG2 PRRG4 RTN4IP1 RUNX1 SUMO3 TCP11L1 TEAD2 TEAD3 TEAD4 WBP2 YWHAE YWHAZ	45 interacting genes: AKT1 ARNT AURKA BCL2L15 BECN1 C14orf39 CCND2 CDK4 CDK6 CDKN2A CDKN2B DACH1 EPHA2 FGFR4 FZR1 GLIS1 GLIS2 GNG13 HGF HIF1A INPP5A LATS2 MAP2K3 MAP2K5 MAP3K5 MYC NCOA1 NEDD4 NFIC NSD3 RAF1 RASSF1 RUNX1 SAA2 SOX3 STK11 TERT TP53 TRIM3 USF2 VGLL1 VGLL3 VGLL4 WWTR1 YAP1
Entrez ID		25937	8463
HPRD ID		09580	03432
Ensembl ID		ENSG00000018408	ENSG00000074219
Uniprot IDs		Q9GZV5	Q15562
PDB IDs		5N5R 5N5T 5N5W 5N75 6RHC 6RJL 6RJQ 6RP6 6SLW 6SLX 8R0Z	3L15 5DQ8 5DQE 5EMV 5HGU 6CDY 6E5G 6S60 6S64 6S66 6S69 6S6J 6UYB 6UYC 6VAH 7OYJ 7T2J 7T2K 7T2L 7T2M 7TYP 7TYQ 7TYU 8CUH 8E1O 8P29 8POJ 8POM 8PON 8PUX 8PUY 8RXL 8RXP 8RXQ 8RXV 8RYC 8YGQ
Enriched GO Terms of Interacting Partners?		Hippo Signaling Intracellular Signal Transduction Phosphoserine Residue Binding Negative Regulation Of Protein Localization To Nucleus Regulation Of Protein Localization To Nucleus Cell Fate Commitment RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Transcription Regulator Complex Positive Regulation Of Circadian Rhythm Positive Regulation Of Hippo Signaling Negative Regulation Of Immune System Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II	Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Process Protein Kinase Activity Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Cell Cycle Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Epithelial Cell Proliferation Protein Serine Kinase Activity Regulation Of Cell Differentiation Cell Population Proliferation Regulation Of Developmental Process Cellular Response To Stress Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of RNA Metabolic Process Negative Regulation Of Signal Transduction Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of Apoptotic Signaling Pathway Developmental Process Negative Regulation Of Metabolic Process
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