MTHFD1L and FILNC1

Number of citations of the paper that reports this interaction (PubMedID 28978906)
44

Data Source:
BioGRID (unspecified method)

		MTHFD1L	FILNC1
Description		methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	FOXO induced long non-coding RNA 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Cytosol Membrane
	Molecular Function	Nucleotide Binding Formate-tetrahydrofolate Ligase Activity Methylenetetrahydrofolate Dehydrogenase (NADP+) Activity ATP Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Neural Tube Closure One-carbon Metabolic Process Folic Acid-containing Compound Metabolic Process 10-formyltetrahydrofolate Biosynthetic Process Formate Metabolic Process Formate Biosynthetic Process Tetrahydrofolate Interconversion Carboxylic Acid Biosynthetic Process Tetrahydrofolate Metabolic Process Embryonic Neurocranium Morphogenesis Embryonic Viscerocranium Morphogenesis
Pathways		Metabolism of folate and pterines
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 20885792) Chronic myeloid leukemia ( 21540461) Coronary heart disease ( 17634449) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Type 2 diabetes ( 25760438)	Heel bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		2 interacting genes: FILNC1 HGS	88 interacting genes: AAAS ABCC1 ACTN1 ACTR2 AHSA1 AIMP2 AKAP8 ALDH1B1 AP1B1 AP3D1 ARAP1 ARF6 ATP2A2 CAND1 CCT6B CLPX CNDP2 COPG1 DDX24 DNM1 DNM1L DPM1 DYNC1H1 EEF1D EEF2 ERLIN1 GALK1 GMPS GSTO1 HDLBP HNRNPA0 HNRNPD HSPA1A IDH1 KTN1 LAMC1 LAS1L MAP1S MCM3 MRPL4 MSH2 MTHFD1L MYL12A NIBAN2 NKRF NOP56 NPEPPSP1 NSF NUP153 OASL OGT PCAT1 PDCD4 PES1 PFAS PLS3 PPME1 PSMC2 PSMC4 PSMD14 PSMD5 PURA QNG1 RIGI RO60 RPL13A RPS5 RPSA SART1 STT3B STXBP2 TAGLN2 TIMM50 TMEM126A TMX3 TRIP13 TTLL12 TTN U2AF1 UBA52 UBE4A VPS35 WARS1 XPO1 XPOT XRCC6 YWHAB ZCCHC8
Entrez ID		25902	100132735
HPRD ID		09967
Ensembl ID		ENSG00000120254	ENSG00000231426
Uniprot IDs		A0A087WVM4 B2RD24 B7ZM99 Q6UB35
PDB IDs
Enriched GO Terms of Interacting Partners?			RNA Binding Cytosol ATP Hydrolysis Activity Nucleotide Binding Cadherin Binding Ribonucleoprotein Complex Ficolin-1-rich Granule Lumen ATP Binding Extracellular Exosome Proteasome Accessory Complex Cytoplasm Translation Intracellular Transport Proteasome Regulatory Particle, Base Subcomplex Secretory Granule Lumen Nucleoplasm Actin Filament Binding Macromolecule Metabolic Process Nucleolus Mitochondrion-derived Vesicle Intracellular Protein Transport Organelle Localization Cellular Localization Establishment Of Localization In Cell Proteasome Complex Nucleobase-containing Compound Metabolic Process Actin Filament Network Formation ATP-dependent Protein Disaggregase Activity Proteasome-activating Activity LncRNA Binding Membrane Coat Ribosome Cytoplasmic Translation Establishment Of Organelle Localization Double-stranded DNA Binding Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Protein Localization ATP-dependent Protein Folding Chaperone Cellular Component Assembly Regulation Of Cytoplasmic Translation
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