RASGRP3 and GET1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RASGRP3	GET1
Description		RAS guanyl releasing protein 3	guided entry of tail-anchored proteins factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GET Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Kinase Binding Diacylglycerol Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding	Protein Binding Protein-membrane Adaptor Activity
	Biological Process	MAPK Cascade Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Sensory Perception Of Sound Protein Insertion Into ER Membrane Synapse Organization Protein Stabilization Establishment Of Localization In Cell Otic Vesicle Development Tail-anchored Membrane Protein Insertion Into ER Membrane Establishment Of Protein Localization To Membrane
Pathways		Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838193 23273568 26663301 27399966 28714469 33272962)
Interacting Genes		11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		25780	7485
HPRD ID		15213	04224
Ensembl ID		ENSG00000152689	ENSG00000182093
Uniprot IDs		Q8IV61	O00258
PDB IDs			6SO5 8CQZ 8CR1 8CR2
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Positive Regulation Of Establishment Of Protein Localization Kinase Activity Cell Activation Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Peptidyl-serine Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Signaling Pathway Regulation Of Protein Transport Fc Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Protein Kinase Activity Regulation Of Protein Localization Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Cytosol Leukocyte Activation Positive Regulation Of Insulin Secretion Positive Regulation Of Immune System Process Insulin Receptor Substrate Binding Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Cellular Response To Hormone Stimulus Perinuclear Region Of Cytoplasm Protein Phosphorylation Regulation Of Biological Quality Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process	Basolateral Plasma Membrane Membrane Serine Palmitoyltransferase Complex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?