RASGRP3

Gene Name		RAS guanyl releasing protein 3 (calcium and DAG-regulated)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signal Transducer Activity Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Ras GTPase Binding Kinase Binding Diacylglycerol Binding Rap GTPase Activator Activity
	Biological Process	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of RAS in B cells Adaptive Immune System
Drugs
Diseases
GWAS		Hypertension (young onset) ( 19421330) Systemic lupus erythematosus ( 23273568 19838193)
Protein-protein Interactions		9 interactors: APP DYNLL2 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2
Entrez ID		25780
HPRD ID		15213
Ensembl ID		ENSG00000152689
Uniprot IDs		Q8IV61
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cellular Response To Insulin Stimulus Regulation Of Platelet Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune System Process Protein Phosphorylation Regulation Of Wound Healing Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Histone H3-T6 Phosphorylation Regulation Of Platelet Activation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Peptidyl-threonine Phosphorylation Phosphorylation Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Activation Of Phospholipase C Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase C Activity Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Positive Regulation Of Phospholipase Activity
Tagcloud ?		activating arthritis cas9 colitis coupling crispr destruct dextrane editing elucidated excessive gtpases guanine impairs invading limits nucleotide rap rap1 raw264 releasing relieves sulphate switches threshold tlr tlr3 toll