RASGRP3 and SULT1C2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RASGRP3	SULT1C2
Gene Name		RAS guanyl releasing protein 3 (calcium and DAG-regulated)	sulfotransferase family, cytosolic, 1C, member 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function	Signal Transducer Activity Guanyl-nucleotide Exchange Factor Activity Ras Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Ras GTPase Binding Kinase Binding Diacylglycerol Binding Rap GTPase Activator Activity	Sulfotransferase Activity
	Biological Process	MAPK Cascade Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Positive Regulation Of Rap GTPase Activity Positive Regulation Of GTPase Activity	Xenobiotic Metabolic Process Amine Metabolic Process Small Molecule Metabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		Signaling by the B Cell Receptor (BCR) Downstream signaling events of B Cell Receptor (BCR) Activation of RAS in B cells Adaptive Immune System	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Defective UGT1A1 causes hyperbilirubinemia Cytosolic sulfonation of small molecules Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Hypertension (young onset) ( 19421330) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		9 interactors: APP DYNLL2 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	6 interactors: ACD HLTF POT1 RASGRP3 TERF1 TINF2
Entrez ID		25780	6819
HPRD ID		15213	03858
Ensembl ID		ENSG00000152689	ENSG00000198203
Uniprot IDs		Q8IV61	B4DLP0 O00338
PDB IDs			3BFX
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Negative Regulation Of Insulin Receptor Signaling Pathway Response To Wounding Regulation Of Insulin Receptor Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cellular Response To Insulin Stimulus Regulation Of Platelet Aggregation Immune Response-activating Cell Surface Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune System Process Protein Phosphorylation Regulation Of Wound Healing Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Histone H3-T6 Phosphorylation Regulation Of Platelet Activation Regulation Of Cellular Amino Acid Metabolic Process Positive Regulation Of Immune System Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Signaling Pathway Phosphate-containing Compound Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Peptidyl-threonine Phosphorylation Phosphorylation Intracellular Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Activation Of Phospholipase C Activity Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Phospholipase C Activity Regulation Of Cell Adhesion Positive Regulation Of Immune Response Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Positive Regulation Of Phospholipase Activity	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Replication Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of Telomerase Activity Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Telomere Maintenance Via Telomere Lengthening Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Capping Protein Localization To Chromosome, Telomeric Region Chromosome Organization Positive Regulation Of Telomerase Activity DNA Metabolic Process Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Positive Regulation Of DNA Biosynthetic Process RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Protein Localization To Chromosome Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Positive Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Homeostatic Process Organelle Organization Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Positive Regulation Of DNA Strand Elongation Regulation Of Protein ADP-ribosylation Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Cellular Component Assembly Regulation Of Cellular Component Organization Telomeric Loop Formation Telomere Formation Via Telomerase Age-dependent Telomere Shortening Negative Regulation Of Cellular Metabolic Process Telomere Maintenance Via Telomere Shortening Negative Regulation Of Protein Glycosylation Regulation Of Metabolic Process Protection From Non-homologous End Joining At Telomere Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process
Tagcloud ?		activating arthritis cas9 colitis coupling crispr destruct dextrane editing elucidated excessive gtpases guanine impairs invading limits nucleotide rap rap1 raw264 releasing relieves sulphate switches threshold tlr tlr3 toll
Tagcloud (Difference) ?		activating arthritis cas9 colitis coupling crispr destruct dextrane editing elucidated excessive gtpases guanine impairs invading limits nucleotide rap rap1 raw264 releasing relieves sulphate switches threshold tlr tlr3 toll
Tagcloud (Intersection) ?