RASGRP3 and SULT1C2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		RASGRP3	SULT1C2
Description		RAS guanyl releasing protein 3	sulfotransferase family 1C member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Guanyl-nucleotide Exchange Factor Complex Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Lysosome Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Calcium Ion Binding Protein Binding Zinc Ion Binding Kinase Binding Diacylglycerol Binding GTPase Regulator Activity Small GTPase Binding Metal Ion Binding	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Transferase Activity Cholesterol Sulfotransferase Activity
	Biological Process	MAPK Cascade Small GTPase-mediated Signal Transduction Ras Protein Signal Transduction	Amine Metabolic Process Sulfation
Pathways		Activation of RAS in B cells Activation of RAS in B cells RAF/MAP kinase cascade	Cytosolic sulfonation of small molecules
Drugs
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bronchopulmonary dysplasia in preterm infants ( 30113228) Hypertension (young onset) ( 19421330) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Non-albumin protein levels ( 29403010) Non-response to antidepressants and depression ( 27622933) Sjögren's syndrome ( 24097067) Systemic lupus erythematosus ( 19838193 23273568 26663301 27399966 28714469 33272962)	Aluminium levels ( 26025379) Eyebrow thickness ( 26926045) Gut microbiota (functional units) ( 27694959) Parkinson's disease progression (composite) ( 33111402)
Interacting Genes		11 interacting genes: APP DYNLL2 GET1 HSD17B11 PIK3CA PRKACA PRKCB PRKCD PRKCE PRKCQ SULT1C2	6 interacting genes: ACD HLTF POT1 RASGRP3 TERF1 TINF2
Entrez ID		25780	6819
HPRD ID		15213	03858
Ensembl ID		ENSG00000152689	ENSG00000198203
Uniprot IDs		Q8IV61	O00338
PDB IDs			3BFX
Enriched GO Terms of Interacting Partners?		Diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization Regulation Of Superoxide Anion Generation Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Protein Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Superoxide Metabolic Process Positive Regulation Of Establishment Of Protein Localization Kinase Activity Cell Activation Protein Kinase C Signaling Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Peptidyl-serine Phosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Cellular Response To Insulin Stimulus Immune Response-regulating Signaling Pathway Regulation Of Protein Transport Fc Receptor Signaling Pathway Cellular Response To Oxygen-containing Compound Positive Regulation Of Reactive Oxygen Species Metabolic Process Signaling Receptor Activator Activity Protein Kinase Activity Regulation Of Protein Localization Regulation Of Insulin Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cellular Response To Carbohydrate Stimulus Regulation Of Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Cytosol Leukocyte Activation Positive Regulation Of Insulin Secretion Positive Regulation Of Immune System Process Insulin Receptor Substrate Binding Transferase Activity Positive Regulation Of Immune Response Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Intracellular Signal Transduction Cellular Response To Hormone Stimulus Perinuclear Region Of Cytoplasm Protein Phosphorylation Regulation Of Biological Quality Immune Response-activating Signaling Pathway Myeloid Leukocyte Activation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Supramolecular Fiber Organization Regulation Of Reactive Oxygen Species Metabolic Process	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Assembly Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Telomere Maintenance Negative Regulation Of Chromosome Organization Regulation Of DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Organization Negative Regulation Of DNA Metabolic Process RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Chromosome, Telomeric Region Regulation Of Chromosome Organization DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Chromosome Organization DNA Biosynthetic Process Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Regulation Of DNA Metabolic Process Positive Regulation Of Organelle Organization Chromosome Negative Regulation Of Cellular Component Organization Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process DNA Binding Nuclear Body Positive Regulation Of Cellular Component Organization Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly
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