EDARADD and SUMO1P1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		EDARADD	SUMO1P1
Description		EDAR associated via death domain	SUMO1 pseudogene 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus PML Body
	Molecular Function	Protein Binding	Protein Binding Transcription Factor Binding Protein Tag Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Signal Transduction Cell Differentiation	Protein Sumoylation PML Body Organization
Pathways		TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)	Copper levels ( 26025379) Cortical volume ( 32963231) Polycystic ovary syndrome ( 22885925)
Interacting Genes		11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I	33 interacting genes: ACTN3 ARK2N AXIN1 CKS1B EDARADD ESRRG FAM118B FAM200A FHL2 FKBP6 GMCL1 HNRNPC KRTAP9-2 L3MBTL3 LCE2A LCE2D MAPK1IP1L NAB2 PHC1 PIAS1 PIAS2 SATB1 SETBP1 SOX5 STX1A SUMO1 TRAF2 TRIM23 UBA2 UBE2I ZBTB26 ZBTB6 ZNRD2
Entrez ID		128178	391257
HPRD ID		05965
Ensembl ID		ENSG00000186197
Uniprot IDs		A0A1B0GV26 Q8WWZ3
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transcription Factor Binding PML Body Protein Modification Process Regulation Of JNK Cascade Small Protein Activating Enzyme Binding Protein Sumoylation PML Body Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein Polyubiquitination CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Ubiquitin Protein Ligase Activity Nuclear Body Organization Protein Metabolic Process Enzyme Binding Ubiquitin-like Protein Ligase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of T Cell Cytokine Production Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Positive Regulation Of Phosphorylation Ubiquitin-protein Transferase Activity Interleukin-5 Receptor Complex Regulation Of MAPK Cascade TORC2 Complex Disassembly Positive Regulation Of Protein Serine/threonine Kinase Activity SUMO Conjugating Enzyme Activity Protein-N-terminal Glutamine Amidohydrolase Activity Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Interleukin-2 Production Regulation Of MAP Kinase Activity	Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Small Protein Activating Enzyme Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Factor Binding SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Post-translational Protein Modification Presynaptic Cytosol Postsynaptic Cytosol Transcription Corepressor Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Ubiquitin Protein Ligase Binding SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nuclear Body Negative Regulation Of Calcium-mediated Signaling Chromatin Organization Regulation Of Protein Sumoylation Enzyme Binding Synaptonemal Complex Positive Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
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