EDARADD and RNF111

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EDARADD	RNF111
Gene Name		EDAR-associated death domain	ring finger protein 111
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Protein Complex
	Molecular Function		Protein Binding Zinc Ion Binding Ligase Activity SUMO Polymer Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Hair Follicle Development Signal Transduction Cell Differentiation Odontogenesis Of Dentin-containing Tooth Trachea Gland Development	Protein Polyubiquitination Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Pattern Specification Process Gene Expression Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity TGFBR1 LBD Mutants in Cancer SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Loss of Function of TGFBR1 in Cancer Generic Transcription Pathway Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS			Asperger disorder ( 21182207) Metabolite levels ( 22916037)
Protein-Protein Interactions		10 interactors: EDAR RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I WDYHV1	39 interactors: ACTN3 ANAPC11 AXIN1 CREB1 CSNK2A1 CTBP1 DTX3L EDARADD KRTAP5-9 LCE4A LRSAM1 MARCH7 MVP PHF7 PML SMAD3 SMAD6 SMAD7 SMURF2 SUMO2 TRAF5 TRIM21 TRIM8 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2Q2 UBE2V1 UBE2W
Entrez ID		128178	54778
HPRD ID		05965	09318
Ensembl ID		ENSG00000186197	ENSG00000157450
Uniprot IDs		Q8WWZ3	Q6ZNA4
PDB IDs			2KIZ
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Immunoglobulin Secretion Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signaling Positive Regulation Of T Cell Cytokine Production Cellular Protein Modification Process Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of T Cell Cytokine Production Protein Sumoylation Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Regulation Of Binding Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cellular Localization Positive Regulation Of SUMO Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Regulation Of DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Mediated Immunity Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Cellular Protein Modification Process Protein K48-linked Ubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein K11-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Macromolecule Catabolic Process Negative Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteolysis Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Gene Expression Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Chromosome Organization Protein Monoubiquitination Negative Regulation Of Biosynthetic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Cellular Response To Growth Factor Stimulus Response To Growth Factor Cellular Metabolic Process Toll-like Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Protein Catabolic Process Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		chin craniofacial ectodermal ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed
Tagcloud (Difference) ?		chin craniofacial ectodermal ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed
Tagcloud (Intersection) ?