EDARADD and EDAR

Number of citations of the paper that reports this interaction (PubMedID 11882293)
0

Data Source:
HPRD (in vitro)

		EDARADD	EDAR
Description		EDAR associated via death domain	ectodysplasin A receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Membrane Apical Part Of Cell
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Cell Differentiation	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cell Differentiation Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Canonical NF-kappaB Signal Transduction Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of Non-canonical NF-kappaB Signal Transduction
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic	Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Autoimmune thyroid disease ( 32581359) Urate levels (BMI interaction) ( 25811787)	Beard thickness ( 26926045) Blood protein levels ( 30072576) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819) Urinary albumin-to-creatinine ratio ( 32600054)
Interacting Genes		11 interacting genes: EDAR LINC01554 NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I	8 interacting genes: EDA EDARADD MAP3K14 SGTA TRAF1 TRAF2 TRAF3 UPK1B
Entrez ID		128178	10913
HPRD ID		05965	04974
Ensembl ID		ENSG00000186197	ENSG00000135960
Uniprot IDs		A0A1B0GV26 Q8WWZ3	Q9UNE0
PDB IDs			7X9G
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Post-translational Protein Modification Transcription Factor Binding PML Body Protein Modification Process Regulation Of JNK Cascade Small Protein Activating Enzyme Binding Protein Sumoylation PML Body Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Protein Polyubiquitination CD40 Receptor Complex Positive Regulation Of JUN Kinase Activity Positive Regulation Of JNK Cascade Regulation Of Canonical NF-kappaB Signal Transduction Protein Tag Activity Ubiquitin Protein Ligase Activity Nuclear Body Organization Protein Metabolic Process Enzyme Binding Ubiquitin-like Protein Ligase Binding Positive Regulation Of MAPK Cascade Positive Regulation Of T Cell Cytokine Production Presynaptic Cytosol Postsynaptic Cytosol Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Tumor Necrosis Factor Receptor Binding Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Positive Regulation Of Interleukin-2 Production Regulation Of T Cell Cytokine Production Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Protein Ubiquitination Positive Regulation Of Phosphorylation Ubiquitin-protein Transferase Activity Interleukin-5 Receptor Complex Regulation Of MAPK Cascade TORC2 Complex Disassembly Positive Regulation Of Protein Serine/threonine Kinase Activity SUMO Conjugating Enzyme Activity Protein-N-terminal Glutamine Amidohydrolase Activity Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Interleukin-2 Production Regulation Of MAP Kinase Activity	Tumor Necrosis Factor Receptor Binding Thioesterase Binding Tumor Necrosis Factor-mediated Signaling Pathway Signaling Adaptor Activity Regulation Of Canonical NF-kappaB Signal Transduction CD40 Receptor Complex Cytokine-mediated Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Non-canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding TORC2 Complex Disassembly Positive Regulation Of NF-kappaB Transcription Factor Activity Trachea Gland Development TRC Complex Protein Phosphatase Binding TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Response To Other Organism Ubiquitin Ligase Complex Cytoplasmic Side Of Plasma Membrane Positive Regulation Of DNA-binding Transcription Factor Activity Immune Response Apical Plasma Membrane Urothelial Plaque Death Receptor Agonist Activity BAT3 Complex Binding Sphingolipid Binding Response To External Biotic Stimulus IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Hair Follicle Placode Formation Salivary Gland Cavitation CD27 Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of ERAD Pathway Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Toll Signaling Pathway Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRIF-dependent Toll-like Receptor Signaling Pathway Identical Protein Binding Positive Regulation Of JUN Kinase Activity Ubiquitin-protein Transferase Activity Immune System Process
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