EDARADD and EDAR

Number of citations of the paper that reports this interaction (PMID 11882293)
12

Data Source:
HPRD (in vitro)

		EDARADD	EDAR
Gene Name		EDAR-associated death domain	ectodysplasin A receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell
	Molecular Function		Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding
	Biological Process	Hair Follicle Development Signal Transduction Cell Differentiation Odontogenesis Of Dentin-containing Tooth Trachea Gland Development	Hair Follicle Development Apoptotic Process Signal Transduction Epidermis Development Cell Differentiation Positive Regulation Of NF-kappaB Import Into Nucleus Odontogenesis Of Dentin-containing Tooth Pigmentation Salivary Gland Cavitation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: EDAR RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I WDYHV1	6 interactors: EDA EDARADD MAP3K14 TRAF1 TRAF2 TRAF3
Entrez ID		128178	10913
HPRD ID		05965	04974
Ensembl ID		ENSG00000186197	ENSG00000135960
Uniprot IDs		Q8WWZ3	Q9UNE0
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Immunoglobulin Secretion Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signaling Positive Regulation Of T Cell Cytokine Production Cellular Protein Modification Process Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of T Cell Cytokine Production Protein Sumoylation Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Regulation Of Binding Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cellular Localization Positive Regulation Of SUMO Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Regulation Of DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Mediated Immunity Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway	Trachea Gland Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Trachea Development Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response Signal Transduction Toll-like Receptor 4 Signaling Pathway Signaling Cell Communication Hair Follicle Development Hair Cycle Process Cellular Response To Tumor Necrosis Factor Hair Cycle Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway Response To Tumor Necrosis Factor Pattern Recognition Receptor Signaling Pathway Odontogenesis Innate Immune Response-activating Signal Transduction Cellular Response To Stimulus Activation Of Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Immune System Process Positive Regulation Of Immune System Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of MAP Kinase Activity Positive Regulation Of Homotypic Cell-cell Adhesion Apoptotic Process Skin Development Regulation Of I-kappaB Kinase/NF-kappaB Signaling Programmed Cell Death Positive Regulation Of Cell-cell Adhesion Cell Death Regulation Of Innate Immune Response Death Negative Regulation Of Glial Cell Apoptotic Process Salivary Gland Cavitation Response To Stimulus Epidermis Development Activation Of Protein Kinase Activity
Tagcloud ?		chin craniofacial ectodermal ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed	africans appendages backgrounds casts crown dental ectodermal eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a
Tagcloud (Difference) ?		chin craniofacial ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed	africans appendages backgrounds casts crown dental eurasians fgfr2 fras1 genotyped hair japanese koreans metric morphology naf1 nonsynonymous plaster pleiotropic rs10177996 rs7349332 snp snps strongest teeth thada traits wnt10a
Tagcloud (Intersection) ?		ectodermal