EDARADD and SHPRH

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		EDARADD	SHPRH
Gene Name		EDAR-associated death domain	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleosome Nucleus
	Molecular Function		DNA Binding Helicase Activity Ubiquitin-protein Transferase Activity ATP Binding Zinc Ion Binding Ligase Activity
	Biological Process	Hair Follicle Development Signal Transduction Cell Differentiation Odontogenesis Of Dentin-containing Tooth Trachea Gland Development	Protein Polyubiquitination DNA Repair Nucleosome Assembly
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: EDAR RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I WDYHV1	10 interactors: C17orf59 EDARADD FBXW7 FDFT1 LPP PCNA RAD18 UBE2N UBE2V2 YWHAG
Entrez ID		128178	257218
HPRD ID		05965	10476
Ensembl ID		ENSG00000186197	ENSG00000146414
Uniprot IDs		Q8WWZ3	B3KX98 K4DI94 Q149N8
PDB IDs			2M85
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signal Transduction Regulation Of Immunoglobulin Secretion Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Signaling Positive Regulation Of T Cell Cytokine Production Cellular Protein Modification Process Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade Regulation Of T Cell Cytokine Production Protein Sumoylation Activation Of NF-kappaB-inducing Kinase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NIK/NF-kappaB Signaling Protein K63-linked Ubiquitination Positive Regulation Of Interleukin-2 Production NIK/NF-kappaB Signaling Regulation Of Innate Immune Response Regulation Of NIK/NF-kappaB Signaling Protein Autoubiquitination Regulation Of Binding Regulation Of Protein Localization Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cytokine Production Involved In Immune Response Cellular Protein Metabolic Process I-kappaB Kinase/NF-kappaB Signaling TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Positive Regulation Of JUN Kinase Activity Regulation Of Cytokine Production Involved In Immune Response Regulation Of Cellular Localization Positive Regulation Of SUMO Transferase Activity Toll-like Receptor 4 Signaling Pathway Regulation Of JUN Kinase Activity Regulation Of DNA Binding Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of T Cell Mediated Immunity Odontogenesis Of Dentin-containing Tooth Toll-like Receptor Signaling Pathway	Postreplication Repair DNA Double-strand Break Processing Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Metabolic Process Protein Ubiquitination DNA Repair Protein Modification By Small Protein Conjugation Protein K63-linked Ubiquitination DNA Catabolic Process, Exonucleolytic Positive Regulation Of DNA Repair Cellular Response To Stress Regulation Of DNA Repair Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Deoxyribonuclease Activity Negative Regulation Of SREBP Signaling Pathway DNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of DNA Metabolic Process Negative Regulation Of Triglyceride Biosynthetic Process Leading Strand Elongation Regulation Of Response To DNA Damage Stimulus Regulation Of DNA Replication Response To UV Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Farnesyl Diphosphate Metabolic Process Positive Regulation Of Protein Ubiquitination DNA Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Double-strand Break Repair Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Histone Ubiquitination Negative Regulation Of Hepatocyte Proliferation Trachea Gland Development Protein Polyubiquitination Negative Regulation Of DNA Endoreduplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Protein Ubiquitination Cellular Response To Stimulus Positive Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process DNA Recombination Regulation Of Neuron Apoptotic Process Regulation Of DNA Endoreduplication Mitotic Cell Cycle Phase Transition
Tagcloud ?		chin craniofacial ectodermal ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed
Tagcloud (Difference) ?		chin craniofacial ectodermal ectodysplasin eda1 fuller hed hypohidrotic hypoplasia landmarks malformed mandible midface midfacial morphologies morphometrics narrower nose philtrum pointed proportionally protrusive refine rounded sweat umbrella xlhed
Tagcloud (Intersection) ?