PTF1A and PALS2

		PTF1A	PALS2
Description		pancreas associated transcription factor 1a	protein associated with LIN7 2, MAGUK p55 family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Plasma Membrane Cell-cell Junction Membrane Organelle Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Tissue Development Retina Layer Formation Cerebellum Development Central Nervous System Neuron Differentiation Cell Differentiation Hindbrain Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Generation Of Neurons Retina Morphogenesis In Camera-type Eye Regulation Of Neural Retina Development	Protein-containing Complex Assembly
Pathways		Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Type 2 diabetes ( 32499647)
Interacting Genes		11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	31 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A MT2P1 MTREX NDN NFKB1 OGT PARN RPS20 SMARCA4 SNX9 THOP1 VPS26C WEE2-AS1
Entrez ID		256297	51678
HPRD ID		09526	09509
Ensembl ID		ENSG00000168267	ENSG00000105926
Uniprot IDs		Q7RTS3	B8ZZG1 Q9NZW5
PDB IDs
Enriched GO Terms of Interacting Partners?		Photoreceptor Distal Connecting Cilium Microtubule Cytoskeleton Transcription Regulator Complex Positive Regulation Of Ephrin Receptor Signaling Pathway DNA-binding Transcription Factor Binding Arterial Endothelial Cell Fate Commitment E-box Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Photoreceptor Connecting Cilium Photoreceptor Connecting Cilium Intercellular Bridge MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Neuron Differentiation Beta-catenin-TCF7L2 Complex Negative Regulation Of RRNA Processing N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Regulation Of Embryonic Development Histone H3K9 Acetyltransferase Activity RZZ Complex Dsl1/NZR Complex Heterochromatin Boundary Formation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Club Cell Differentiation Epidermal Cell Fate Specification Aortic Valve Development Pulmonary Valve Development Hair Follicle Maturation Regulation Of Generation Of Precursor Metabolites And Energy Endocardium Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Endothelial Cell Fate Specification Semi-lunar Valve Development TFIIB-class Transcription Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Sister Chromatid Segregation Regulation Of Ribosome Biogenesis Regulation Of Chromosome Segregation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Centromeric DNA Binding Axoneme Protein Localization To Ciliary Transition Zone	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance RNA Exonuclease Activity U4 SnRNA 3'-end Processing Nuclear RNA Surveillance RNA Surveillance 3'-5'-RNA Exonuclease Activity RRNA Catabolic Process SnRNA Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process SnRNA 3'-end Processing RNA 3'-end Processing MRNA Catabolic Process RNA Catabolic Process Exoribonuclease Complex SnRNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process RRNA 3'-end Processing TRNA Decay RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process MRNA Metabolic Process RNA Binding U5 SnRNA 3'-end Processing U1 SnRNA 3'-end Processing Nucleolus RNA Metabolic Process CUT Catabolic Process RNA Processing Negative Regulation Of Gene Expression MRNA 3'-UTR AU-rich Region Binding Macromolecule Catabolic Process DNA Deamination Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Maturation Of 5.8S RRNA Cytoplasm Catabolic Process DNA Modification Negative Regulation Of Macromolecule Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?