PTF1A and TRIP12

Number of citations of the paper that reports this interaction (PMID 25355311)
0

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PTF1A	TRIP12
Gene Name		pancreas specific transcription factor, 1a	thyroid hormone receptor interactor 12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Transcription Factor Complex Cytoplasm	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding	Ubiquitin-protein Transferase Activity Protein Binding Ligase Activity Thyroid Hormone Receptor Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Embryo Development Tissue Development Retina Layer Formation Cerebellum Development Pancreas Development Exocrine Pancreas Development Endocrine Pancreas Development Amacrine Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Regulation Of Neural Retina Development	DNA Repair Cellular Response To DNA Damage Stimulus Embryo Development Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Regulation of beta-cell development Regulation of gene expression in early pancreatic precursor cells	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		11 interactors: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	14 interactors: ATF7IP CARNS1 CDKN2A CELSR3 CLSTN1 NAE1 NMI PTF1A SMAD9 SOX6 THRB UBE2D1 UBE2L3 UBE4B
Entrez ID		256297	9320
HPRD ID		09526	05144
Ensembl ID		ENSG00000168267	ENSG00000153827
Uniprot IDs		Q7RTS3	Q14669
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gluconeogenesis Transcription Initiation From RNA Polymerase II Promoter Regulation Of Glycoprotein Biosynthetic Process DNA-templated Transcription, Initiation Positive Regulation Of Glucose Metabolic Process Myoblast Differentiation Regulation Of Gluconeogenesis Pituitary Gland Development Transcription From RNA Polymerase II Promoter Somatic Stem Cell Maintenance Regulation Of Cell Cycle Protein Localization To Photoreceptor Outer Segment Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Positive Regulation Of Ephrin Receptor Signaling Pathway Arterial Endothelial Cell Fate Commitment Epidermal Cell Fate Specification Protein Localization To Photoreceptor Connecting Cilium Regulation Of BMP Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Diencephalon Development Negative Regulation Of Cell Cycle Regulation Of Organ Growth Histone H3-K9 Acetylation Regulation Of Protein ADP-ribosylation Blood Vessel Lumenization Catenin Import Into Nucleus Blood Vessel Endothelial Cell Fate Specification Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Muscle Structure Development Blood Vessel Development Protein Localization To Organelle Vasculature Development Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Negative Regulation Of Histone H2A K63-linked Ubiquitination Protein Localization To Nonmotile Primary Cilium N-terminal Peptidyl-lysine Acetylation Endothelial Cell Fate Specification Regulation Of Striated Muscle Tissue Development Notch Signaling Pathway Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Histone Ubiquitination Negative Regulation Of Protein K63-linked Ubiquitination Maintenance Of DNA Repeat Elements Clara Cell Differentiation Cell Cycle Arrest Stem Cell Maintenance Regulation Of Carbohydrate Metabolic Process Interleukin-4 Secretion	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Stimulus Positive Regulation Of Macromolecule Biosynthetic Process Protein Polyubiquitination Positive Regulation Of Gene Expression Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Cellular Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Response To Transforming Growth Factor Beta Regulation Of RNA Biosynthetic Process Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of Cell Cycle Phase Transition Negative Regulation Of RNA Biosynthetic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Carnosine Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Biosynthetic Process Signal Transduction Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity BMP Signaling Pathway Regulation Of Transcription, DNA-templated
Tagcloud ?		anlage atohla augmentation cerebellar fertilization granule hepatocyte hpf inc klf8 kruppel lip met modulates morphants morpholino mosp neurobiol periodicals perturbed primordium purkinje rescued rhombic rhombomere substantially tectum wiley zebrafish	aberrant alternative aml another arf catabolic cd8 clean confidential degs differentially donors events exon3 gb integrated investigations isoform ligase macromolecule mononuclear pairs profiling remission sequencing skipping splicing suppresses validated
Tagcloud (Difference) ?		anlage atohla augmentation cerebellar fertilization granule hepatocyte hpf inc klf8 kruppel lip met modulates morphants morpholino mosp neurobiol periodicals perturbed primordium purkinje rescued rhombic rhombomere substantially tectum wiley zebrafish	aberrant alternative aml another arf catabolic cd8 clean confidential degs differentially donors events exon3 gb integrated investigations isoform ligase macromolecule mononuclear pairs profiling remission sequencing skipping splicing suppresses validated
Tagcloud (Intersection) ?