PTF1A and SPATA7

Number of citations of the paper that reports this interaction (PubMedID 25355311)
39

Data Source:
BioGRID (two hybrid)

		PTF1A	SPATA7
Description		pancreas associated transcription factor 1a	spermatogenesis associated 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Photoreceptor Outer Segment Cytoplasm Cytoskeleton Axoneme Microtubule Cytoskeleton Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Rod Photoreceptor Outer Segment Photoreceptor Distal Connecting Cilium
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Tissue Development Retina Layer Formation Cerebellum Development Central Nervous System Neuron Differentiation Cell Differentiation Hindbrain Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Generation Of Neurons Retina Morphogenesis In Camera-type Eye Regulation Of Neural Retina Development	Microtubule Cytoskeleton Organization Visual Perception Photoreceptor Cell Maintenance Protein Localization To Photoreceptor Outer Segment Protein Localization To Photoreceptor Connecting Cilium
Pathways		Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)	Leber congenital amaurosis (LCR) Retinitis pigmentosa (RP)
GWAS		Type 2 diabetes ( 32499647)	Attention deficit hyperactivity disorder ( 30563984) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Coronary artery calcification ( 23870195) Estimated glomerular filtration rate ( 31152163 31451708) Information processing speed ( 21130836)
Interacting Genes		11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	3 interacting genes: APP HSPB1 PTF1A
Entrez ID		256297	55812
HPRD ID		09526	15431
Ensembl ID		ENSG00000168267	ENSG00000042317
Uniprot IDs		Q7RTS3	Q9P0W8 V9HVY9
PDB IDs
Enriched GO Terms of Interacting Partners?		Photoreceptor Distal Connecting Cilium Microtubule Cytoskeleton Transcription Regulator Complex Positive Regulation Of Ephrin Receptor Signaling Pathway DNA-binding Transcription Factor Binding Arterial Endothelial Cell Fate Commitment E-box Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Photoreceptor Connecting Cilium Photoreceptor Connecting Cilium Intercellular Bridge MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Neuron Differentiation Beta-catenin-TCF7L2 Complex Negative Regulation Of RRNA Processing N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Regulation Of Embryonic Development Histone H3K9 Acetyltransferase Activity RZZ Complex Dsl1/NZR Complex Heterochromatin Boundary Formation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Club Cell Differentiation Epidermal Cell Fate Specification Aortic Valve Development Pulmonary Valve Development Hair Follicle Maturation Regulation Of Generation Of Precursor Metabolites And Energy Endocardium Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Endothelial Cell Fate Specification Semi-lunar Valve Development TFIIB-class Transcription Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Sister Chromatid Segregation Regulation Of Ribosome Biogenesis Regulation Of Chromosome Segregation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Centromeric DNA Binding Axoneme Protein Localization To Ciliary Transition Zone	Amyloid-beta Complex Positive Regulation Of Interleukin-1 Production Growth Cone Lamellipodium Axo-dendritic Transport Regulation Of Response To Calcium Ion Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Interleukin-1 Beta Production Negative Regulation Of Protein Kinase C Signaling Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cytoskeleton-dependent Intracellular Transport Regulation Of Chemotaxis Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemotaxis Microtubule-based Transport Transport Along Microtubule Regulation Of Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Protein Kinase C Inhibitor Activity Regulation Of Neural Retina Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Growth Factor Stimulus Growth Factor Receptor Binding Main Axon Regulation Of Protein Kinase C Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Response To Growth Factor Regulation Of Synapse Structure Or Activity
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