PTF1A and RBPJ

Number of citations of the paper that reports this interaction (PubMedID 25355311)
39

Data Source:
BioGRID (two hybrid)

		PTF1A	RBPJ
Description		pancreas associated transcription factor 1a	recombination signal binding protein for immunoglobulin kappa J region
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin MAML1-RBP-Jkappa- ICN1 Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Transcription Repressor Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Nervous System Development Tissue Development Retina Layer Formation Cerebellum Development Central Nervous System Neuron Differentiation Cell Differentiation Hindbrain Development Pancreas Development Exocrine Pancreas Development Developmental Process Amacrine Cell Differentiation Cell Fate Commitment Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Neuron Fate Commitment Generation Of Neurons Retina Morphogenesis In Camera-type Eye Regulation Of Neural Retina Development	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Somitogenesis Epithelial To Mesenchymal Transition Blood Vessel Remodeling Inflammatory Response To Antigenic Stimulus Secondary Heart Field Specification Outflow Tract Morphogenesis Endocardium Development Endocardium Morphogenesis Aortic Valve Development Pulmonary Valve Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Cardiac Left Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Heart Development Cell Population Proliferation Auditory Receptor Cell Fate Commitment Epidermal Cell Fate Specification Regulation Of Gene Expression Positive Regulation Of Gene Expression Pituitary Gland Development Hemopoiesis Cell Differentiation Neuron Differentiation B Cell Differentiation Keratinocyte Differentiation Negative Regulation Of Ossification Positive Regulation Of BMP Signaling Pathway Somatic Stem Cell Population Maintenance Dorsal Aorta Morphogenesis Atrioventricular Canal Development Defense Response To Bacterium Myeloid Dendritic Cell Differentiation Regulation Of Generation Of Precursor Metabolites And Energy Cell Fate Commitment Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Timing Of Cell Differentiation Animal Organ Development Sebaceous Gland Development Hair Follicle Maturation Artery Morphogenesis Epithelial Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Cell Myoblast Differentiation Ventricular Septum Morphogenesis Club Cell Differentiation Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Stem Cell Proliferation Blood Vessel Lumenization Positive Regulation Of Canonical Wnt Signaling Pathway Blood Vessel Endothelial Cell Fate Specification Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Ephrin Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Stem Cell Proliferation
Pathways		Regulation of gene expression in early pancreatic precursor cells Developmental Lineage of Pancreatic Acinar Cells	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Formation of paraxial mesoderm Somitogenesis
Drugs
Diseases		Permanent neonatal diabetes mellitus (PNDM)
GWAS		Type 2 diabetes ( 32499647)	A body shape index ( 34021172) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Autoimmune traits (pleiotropy) ( 30572963) Heel bone mineral density ( 30598549) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Rheumatoid arthritis ( 23143596 24449572) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Takayasu arteritis ( 33308445) Triglyceride levels ( 32203549 32154731) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		11 interacting genes: AAMP CCDC27 CCNDBP1 KAT2B RBPJ RPGRIP1 SPATA7 TCF12 TCF4 TRIP12 ZW10	29 interacting genes: APP CCNF CIRSR FHL1 GADD45A GSK3B HDAC1 HMGB1 HSPB1 KAT2A KAT2B MAML1 MED27 NCOR1 NCOR2 NOTCH1 NOTCH2 NOTCH3 NOTCH4 PTF1A PTOV1 RPS6KA6 SIN3A SND1 SNW1 SPEN SPOP SUFU TP53
Entrez ID		256297	3516
HPRD ID		09526	00920
Ensembl ID		ENSG00000168267	ENSG00000168214
Uniprot IDs		Q7RTS3	Q06330
PDB IDs			2F8X 3NBN 3V79 6PY8
Enriched GO Terms of Interacting Partners?		Photoreceptor Distal Connecting Cilium Microtubule Cytoskeleton Transcription Regulator Complex Positive Regulation Of Ephrin Receptor Signaling Pathway DNA-binding Transcription Factor Binding Arterial Endothelial Cell Fate Commitment E-box Binding Regulation Of Attachment Of Spindle Microtubules To Kinetochore Protein Localization To Photoreceptor Connecting Cilium Photoreceptor Connecting Cilium Intercellular Bridge MAML1-RBP-Jkappa- ICN1 Complex Endocardium Morphogenesis Blood Vessel Endothelial Cell Fate Specification Blood Vessel Lumenization Auditory Receptor Cell Fate Commitment Regulation Of Cell Adhesion Involved In Heart Morphogenesis Positive Regulation Of Neuron Differentiation Beta-catenin-TCF7L2 Complex Negative Regulation Of RRNA Processing N-terminal Peptidyl-lysine Acetylation Diamine N-acetyltransferase Activity Regulation Of Embryonic Development Histone H3K9 Acetyltransferase Activity RZZ Complex Dsl1/NZR Complex Heterochromatin Boundary Formation Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Club Cell Differentiation Epidermal Cell Fate Specification Aortic Valve Development Pulmonary Valve Development Hair Follicle Maturation Regulation Of Generation Of Precursor Metabolites And Energy Endocardium Development DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Endothelial Cell Fate Specification Semi-lunar Valve Development TFIIB-class Transcription Factor Binding Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Sister Chromatid Segregation Regulation Of Ribosome Biogenesis Regulation Of Chromosome Segregation L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Negative Regulation Of Ribosome Biogenesis Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Centromeric DNA Binding Axoneme Protein Localization To Ciliary Transition Zone	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Transcription Repressor Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Corepressor Activity Nucleoplasm Regulation Of Developmental Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Notch Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleus Transcription Coactivator Activity Histone Deacetylase Binding Regulation Of MiRNA Transcription Positive Regulation Of Cell Differentiation Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of MiRNA Metabolic Process Regulation Of Cell Differentiation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Notch Binding Regulation Of Primary Metabolic Process Atrioventricular Node Development Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription Of Notch Receptor Target Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Metabolic Process Positive Regulation Of Muscle Cell Differentiation Chromatin Binding Regulation Of Muscle Cell Differentiation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Epigenetic Regulation Of Gene Expression Developmental Process
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