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NSF and STX4
Number of citations of the paper that reports this interaction (PubMedID
8973549
)
32
Data Source:
BioGRID
(proximity labelling technology)
HPRD
(in vivo)
NSF
STX4
Description
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
syntaxin 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Lysosomal Membrane
Golgi Apparatus
Golgi Stack
Cytosol
Plasma Membrane
Dendritic Shaft
GABA-ergic Synapse
Postsynaptic Specialization, Intracellular Component
Storage Vacuole
Extracellular Space
Cytoplasm
Endosome
Vacuole
Trans-Golgi Network
Cytosol
Plasma Membrane
Cell Surface
Endomembrane System
Membrane
Basolateral Plasma Membrane
Lamellipodium
Phagocytic Vesicle Membrane
SNARE Complex
Stereocilium
Neuron Projection Membrane
Myelin Sheath Adaxonal Region
Somatodendritic Compartment
Specific Granule
Cell Projection
Neuron Projection
Dendritic Spine
Lateral Loop
Synapse
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Postsynapse
Glutamatergic Synapse
Molecular Function
SNARE Binding
Nucleotide Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Syntaxin-1 Binding
Protein Kinase Binding
Syntaxin Binding
PDZ Domain Binding
Ionotropic Glutamate Receptor Binding
Protein-containing Complex Binding
Metal Ion Binding
ATP-dependent Protein Disaggregase Activity
SNARE Binding
SNAP Receptor Activity
Protein Binding
Sphingomyelin Phosphodiesterase Activator Activity
Biological Process
Positive Regulation Of Receptor Recycling
Potassium Ion Transport
Intracellular Protein Transport
Exocytosis
Intra-Golgi Vesicle-mediated Transport
Protein Transport
Vesicle-mediated Transport
Regulation Of Exocytosis
SNARE Complex Disassembly
Golgi To Plasma Membrane Protein Transport
Plasma Membrane Fusion
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Immunoglobulin Production
Neurotransmitter Transport
Intracellular Protein Transport
Exocytosis
Vesicle Fusion
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Vesicle-mediated Transport
Regulation Of Exocytosis
Positive Regulation Of Cell Migration
Protein Localization To Cell Surface
Cellular Response To Oxidative Stress
SNARE Complex Assembly
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Positive Regulation Of Catalytic Activity
Positive Regulation Of Eosinophil Degranulation
Positive Regulation Of Cell Adhesion
Vesicle Docking
Organelle Fusion
Positive Regulation Of Chemotaxis
Long-term Synaptic Potentiation
Membrane Organization
Cellular Response To Type II Interferon
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Protein Localization To Plasma Membrane
Cornified Envelope Assembly
Positive Regulation Of Protein Localization To Cell Surface
Pathways
COPII-mediated vesicle transport
Trafficking of GluR2-containing AMPA receptors
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
Intra-Golgi traffic
Retrograde transport at the Trans-Golgi-Network
Disinhibition of SNARE formation
ER-Phagosome pathway
Translocation of SLC2A4 (GLUT4) to the plasma membrane
trans-Golgi Network Vesicle Budding
Other interleukin signaling
Drugs
1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS
Alcohol use disorder (total score) (
30336701
)
Body mass index (
26426971
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (
32963231
)
Cortical surface area (global PC1) (
32198502
)
Cortical volume (
32963231
)
General factor of neuroticism (
30867560
)
Handedness (Left-handed vs. non-left-handed) (
30980028
)
Handedness (Right-handed vs. non-right-handed) (
30980028
)
Hemoglobin levels (
32327693
)
Hypertrophic cardiomyopathy (
33495596
)
Hypertrophic cardiomyopathy (MTAG) (
33495596
)
Intelligence (MTAG) (
29326435
)
Intraocular pressure (
30054594
)
Macular thickness (
30535121
)
Male-pattern baldness (
28196072
)
Parkinson's disease (
21812969
19915575
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Reaction time (
29844566
)
Refractive error (
32231278
)
Sense of smell (
26632684
)
Thyroid stimulating hormone levels (
30367059
)
Response to metformin (IC50) (
28173075
)
Triglyceride levels (
32203549
)
Interacting Genes
31 interacting genes:
ARRB1
ASPSCR1
CD28
CEP126
DRD2
EIF3E
ERG28
ESR1
FILNC1
FUNDC2
GABARAP
GABARAPL2
GABBR1
GABBR2
GOSR1
GRIA2
GRIA3
LUC7L2
MEOX2
NAPA
NAPG
PLK2
PTPN9
RAMP3
RNF10
RPLP1
STX1A
STX4
STX8
USO1
VAPA
65 interacting genes:
ABI2
ACTB
ANKRD46
BET1
CYBRD1
DLG1
DNAJC5
FAXDC2
GIMAP5
GOSR2
GPR152
ITSN2
LLGL1
LMNA
NAPA
NAPB
NSF
PLP1
PSMA3
RAB11A
RAB4A
RAB5A
RNF4
SCRIB
SEC22A
SEC22B
SEPTIN5
SERP1
SGPL1
SH3GLB2
SNAP23
SNAP25
SNAP47
STX10
STX11
STX16
STX1A
STX1B
STX2
STX3
STX5
STXBP3
STXBP4
STXBP5
STXBP6
SYT1
SYT4
SYT7
TCEANC
TMEM203
TRAF3IP3
TXLNA
TXLNB
TXLNG
USE1
VAMP1
VAMP2
VAMP3
VAMP4
VAMP7
VAMP8
VAPB
VMA12
VTI1B
ZFPL1
Entrez ID
4905
6810
HPRD ID
03380
01722
Ensembl ID
ENSG00000073969
ENSG00000103496
Uniprot IDs
A0A384MTI6
P46459
B7Z425
Q12846
PDB IDs
6KZQ
Enriched GO Terms of Interacting Partners
?
Membrane Fusion
SNARE Complex
Intracellular Protein Localization
SNARE Binding
Protein Transport
Organelle Localization By Membrane Tethering
Vesicle-mediated Transport
Intra-Golgi Vesicle-mediated Transport
Membrane Docking
SNAP Receptor Activity
Vesicle Fusion
Establishment Of Protein Localization
Chemical Synaptic Transmission
Organelle Membrane Fusion
Trans-synaptic Signaling
Synaptic Signaling
G Protein-coupled GABA Receptor Activity
G Protein-coupled GABA Receptor Complex
G Protein-coupled Receptor Heterodimeric Complex
Organelle Fusion
Intracellular Protein Transport
Vesicle Docking
Positive Regulation Of Synaptic Transmission
Dendritic Spine
Regulation Of Protein Localization To Cell Periphery
GABA Receptor Complex
Golgi Vesicle Transport
Soluble NSF Attachment Protein Activity
Regulation Of Protein Localization To Membrane
Membrane Organization
Negative Regulation Of Dopamine Secretion
Vesicle Organization
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Modulation Of Chemical Synaptic Transmission
Intracellular Transport
Regulation Of Postsynaptic Membrane Potential
Neuron-glial Cell Signaling
Regulation Of Catecholamine Secretion
Negative Regulation Of Synaptic Transmission
Establishment Of Localization In Cell
GABA Receptor Activity
AMPA Glutamate Receptor Activity
Postsynaptic Membrane
Regulation Of Protein Localization To Plasma Membrane
ATP-dependent Protein Binding
Chloride Channel Inhibitor Activity
Synaptic Transmission, Glutamatergic
Cell-cell Signaling
Syntaxin Binding
Endomembrane System
SNAP Receptor Activity
SNARE Complex
Membrane Fusion
Syntaxin Binding
Vesicle Fusion
Organelle Membrane Fusion
Organelle Fusion
Vesicle-mediated Transport
Membrane Organization
SNARE Binding
Vesicle Organization
Exocytosis
Organelle Localization By Membrane Tethering
Establishment Of Localization In Cell
Membrane Docking
Secretion By Cell
Vesicle Docking
Protein Transport
Secretion
Establishment Of Protein Localization
Vesicle-mediated Transport In Synapse
Golgi Vesicle Transport
Cellular Localization
Intracellular Protein Localization
Intracellular Transport
Organelle Localization
Regulation Of Vesicle-mediated Transport
Endomembrane System
Calcium-ion Regulated Exocytosis
SNARE Complex Assembly
Membrane
Regulated Exocytosis
Regulation Of Exocytosis
Syntaxin-1 Binding
Synaptic Vesicle Exocytosis
Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane
Intracellular Protein Transport
Vesicle Fusion To Plasma Membrane
Regulation Of Secretion By Cell
Synaptic Vesicle Membrane
Regulation Of Secretion
Synaptic Vesicle Membrane Organization
Signal Release
Regulation Of Transport
Regulation Of Regulated Secretory Pathway
Synaptic Vesicle
Calcium Ion-regulated Exocytosis Of Neurotransmitter
Vesicle Docking Involved In Exocytosis
Synaptobrevin 2-SNAP-25-syntaxin-1a Complex
Post-Golgi Vesicle-mediated Transport
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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