NSF and GRIA2

Number of citations of the paper that reports this interaction (PubMedID 20802490)
50

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		NSF	GRIA2
Description		N-ethylmaleimide sensitive factor, vesicle fusing ATPase	glutamate ionotropic receptor AMPA type subunit 2
Image
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Dendritic Shaft GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Plasma Membrane External Side Of Plasma Membrane Postsynaptic Density Membrane Dendrite Endocytic Vesicle Membrane Asymmetric Synapse AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Postsynapse Postsynaptic Density Membrane Postsynaptic Endocytic Zone
	Molecular Function	SNARE Binding Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Syntaxin-1 Binding Protein Kinase Binding Syntaxin Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding ATP-dependent Protein Disaggregase Activity	Amyloid-beta Binding Glutamate-gated Receptor Activity AMPA Glutamate Receptor Activity Monoatomic Ion Channel Activity Protein Binding Ligand-gated Monoatomic Ion Channel Activity Signaling Receptor Activity Ligand-gated Monoatomic Cation Channel Activity Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Monoatomic Cation Transmembrane Transport
Pathways		COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Activation of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation MECP2 regulates neuronal receptors and channels Long-term potentiation
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione	Glutamic acid Butabarbital Butalbital Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Ethanol Phenobarbital Quinidine barbiturate Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione (S)-DES-ME-AMPA (S)-AMPA 2-Amino-3-(5-Tert-Butyl-3-(Phosphonomethoxy)-4-Isoxazolyl)Propionic Acid Iodo-Willardiine Fluoro-Willardiine Quisqualic acid (S)-2-Amino-3-(1,3,5,7-Pentahydro-2,4-Dioxo-Cyclopenta[E]Pyrimidin-1-Yl) Proionic Acid (2S)-2-Ammonio-3-[5-(2-methyl-2-propanyl)-3-oxido-1,2-oxazol-4-yl]propanoate FG-9041 Bromo-Willardiine Willardiine 2-Amino-3-(3-Hydroxy-7,8-Dihydro-6h-Cyclohepta[D]-4-Isoxazolyl)Propionic Acid Aniracetam THIO-ATPA Talampanel CX-717 N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide Fluciclovine (18F)
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 21812969 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)	Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		31 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FILNC1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PLK2 PTPN9 RAMP3 RNF10 RPLP1 STX1A STX4 STX8 USO1 VAPA	21 interacting genes: CTTN CYLD DRD2 FXR1 GAPDH GRIA3 GRIP2 GSK3B GTF3C2 ITGB3 NSF PICK1 PRKCA RAC1 RNF167 SDCBP SPTAN1 SPTBN1 SQSTM1 SYT3 TSPAN7
Entrez ID		4905	2891
HPRD ID		03380	04726
Ensembl ID		ENSG00000073969	ENSG00000120251
Uniprot IDs		A0A384MTI6 P46459	A0A994J4F1 P42262
PDB IDs		6KZQ	2WJW 2WJX 2XHD 3R7X 3RN8 3RNN 3UA8 5H8S 5YBF 5YBG 5ZG0 5ZG1 5ZG2 5ZG3 7F3O 8I0B
Enriched GO Terms of Interacting Partners?		Membrane Fusion SNARE Complex Intracellular Protein Localization SNARE Binding Protein Transport Organelle Localization By Membrane Tethering Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Membrane Docking SNAP Receptor Activity Vesicle Fusion Establishment Of Protein Localization Chemical Synaptic Transmission Organelle Membrane Fusion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Organelle Fusion Intracellular Protein Transport Vesicle Docking Positive Regulation Of Synaptic Transmission Dendritic Spine Regulation Of Protein Localization To Cell Periphery GABA Receptor Complex Golgi Vesicle Transport Soluble NSF Attachment Protein Activity Regulation Of Protein Localization To Membrane Membrane Organization Negative Regulation Of Dopamine Secretion Vesicle Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Modulation Of Chemical Synaptic Transmission Intracellular Transport Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Establishment Of Localization In Cell GABA Receptor Activity AMPA Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Protein Localization To Plasma Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Synaptic Transmission, Glutamatergic Cell-cell Signaling Syntaxin Binding Endomembrane System	Glutamatergic Synapse Plasma Membrane Regulation Of Synaptic Plasticity Regulation Of Biological Quality Positive Regulation Of Signaling Regulation Of Organelle Organization Synapse Modulation Of Chemical Synaptic Transmission Regulation Of Signaling Regulation Of Cytoskeleton Organization Regulation Of Vesicle-mediated Transport Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Cell Communication Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Cellular Component Organization Chemical Synaptic Transmission Regulation Of Receptor Internalization Localization Within Membrane Trans-synaptic Signaling Regulation Of Actin Cytoskeleton Organization Synaptic Signaling Regulation Of Secretion By Cell Alphav-beta3 Integrin-PKCalpha Complex Vesicle-mediated Transport Regulation Of Actin Filament-based Process Ionotropic Glutamate Receptor Binding Regulation Of Secretion Cellular Component Assembly Postsynapse Membrane Membrane Organization Positive Regulation Of Signal Transduction Regulation Of Cellular Component Size Positive Regulation Of Protein Localization Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Actin Filament Polymerization Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Actin Filament Organization Positive Regulation Of Developmental Process Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Neuron Projection Organization Regulation Of Actin Polymerization Or Depolymerization Protein Kinase C Binding Regulation Of Actin Filament Length Intracellular Membraneless Organelle
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