NSF and VAPA

Number of citations of the paper that reports this interaction (PMID 11511104)
14

Data Source:
HPRD (in vitro)

		NSF	VAPA
Gene Name		N-ethylmaleimide-sensitive factor	VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Extracellular Vesicular Exosome	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Vesicle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Rab GTPase Binding Protein Kinase Binding PDZ Domain Binding Protein Complex Binding ATPase Activity, Coupled Metal Ion Binding	Signal Transducer Activity Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Receptor Recycling Potassium Ion Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Synaptic Transmission Vesicle-mediated Transport Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Golgi Vesicle Docking	Sphingolipid Metabolic Process ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Signal Transduction Cell Death Sphingolipid Biosynthetic Process Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Small Molecule Metabolic Process Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses	Sphingolipid metabolism Metabolism of lipids and lipoproteins Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Parkinson's disease ( 19915575 21812969)	Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		25 interactors: ARRB1 C14orf1 CD28 DRD2 EIF3E FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 KIAA1377 LUC7L2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA	15 interactors: ADRB2 APOD APP CACNG1 EGFR GPR128 NSF OPRM1 OSBP RMDN3 SIK1 VAMP1 VAMP2 VAPB ZBTB22
Entrez ID		4905	9218
HPRD ID		03380	09299
Ensembl ID		ENSG00000073969	ENSG00000101558
Uniprot IDs		P46459	Q9P0L0
PDB IDs			2RR3
Enriched GO Terms of Interacting Partners?		Membrane Fusion Membrane Organization Intracellular Transport Golgi Vesicle Transport Protein Localization Establishment Of Localization In Cell Protein Transport Synaptic Transmission Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cell-cell Signaling Intracellular Protein Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Protein Localization Neuron-neuron Synaptic Transmission Organelle Fusion Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Vesicle Organization Negative Regulation Of CAMP Biosynthetic Process Transport Mitochondrion Degradation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Organelle Disassembly Synaptic Transmission, Glutamatergic Receptor Internalization Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase Activity Regulation Of Vesicle-mediated Transport Regulation Of Cyclase Activity Regulation Of Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cytoplasmic Transport Regulation Of Cellular Localization G-protein Coupled Receptor Internalization Regulation Of Peptide Hormone Secretion Cellular Component Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Receptor Metabolic Process Vesicle Docking Post-Golgi Vesicle-mediated Transport Regulation Of CAMP Biosynthetic Process Membrane Docking Regulation Of Protein Localization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway	Metal Ion Homeostasis Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Localization Exocytosis Membrane Fusion Cellular Metal Ion Homeostasis Golgi To Plasma Membrane Protein Transport Establishment Of Localization In Cell Homeostatic Process Membrane Organization Cellular Cation Homeostasis Chemical Homeostasis Cellular Ion Homeostasis Vesicle-mediated Transport Transport Intracellular Transport Golgi To Plasma Membrane Transport Secretion By Cell Cellular Chemical Homeostasis Vesicle Organization Regulation Of Cellular Localization Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Vasodilation Establishment Of Protein Localization To Membrane Vesicle Fusion Regulation Of Ion Transport Regulation Of Protein Transport Secretion Regulation Of Intracellular Protein Transport Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Golgi Vesicle Transport Regulation Of Adenylate Cyclase Activity Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Establishment Of Protein Localization Negative Regulation Of Wnt Protein Secretion Alkanesulfonate Metabolic Process Negative Regulation Of T Cell Migration Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation By Host Of Viral Release From Host Cell Cytoplasmic Transport Cellular Homeostasis Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Cyclase Activity Regulation Of Sodium Ion Transport Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Tagcloud ?		acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles	abolished acetate acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif myristate orp3 oxysterol phenylalanines phorbol pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Difference) ?		alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles	abolished acidic akts473 beta1 canonical consistently disruption ffat homolog homology hyperphosphorylated integrin interacting mechanistic motif orp3 oxysterol phenylalanines pleckstrin pm pma ras requirements selectively stimulate subcellular
Tagcloud (Intersection) ?		acetate myristate phorbol