NSF and VAPA

Number of citations of the paper that reports this interaction (PubMedID 11511104)
0

Data Source:
HPRD (in vitro)

		NSF	VAPA
Description		N-ethylmaleimide sensitive factor, vesicle fusing ATPase	VAMP associated protein A
Image
GO Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Dendritic Shaft GABA-ergic Synapse Postsynaptic Specialization, Intracellular Component	Golgi Membrane Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Endoplasmic Reticulum Exit Site
	Molecular Function	SNARE Binding Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Syntaxin-1 Binding Protein Kinase Binding Syntaxin Binding PDZ Domain Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding ATP-dependent Protein Disaggregase Activity	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Protein Homodimerization Activity Protein-membrane Adaptor Activity Cadherin Binding Protein Heterodimerization Activity
	Biological Process	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Protein Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process	Sphingomyelin Biosynthetic Process Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Phospholipid Transport Sterol Transport Viral Release From Host Cell Cholesterol Transport Neuron Projection Development Protein Folding In Endoplasmic Reticulum Ceramide Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Membrane Fusion Endoplasmic Reticulum-plasma Membrane Tethering Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network	Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area ( 32963231) Cortical surface area (global PC1) ( 32198502) Cortical volume ( 32963231) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Hypertrophic cardiomyopathy ( 33495596) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 21812969 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)	Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)
Interacting Genes		31 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FILNC1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PLK2 PTPN9 RAMP3 RNF10 RPLP1 STX1A STX4 STX8 USO1 VAPA	47 interacting genes: ADGRG7 ADRB2 APOD AQP6 BIK CACNG1 CD79A CFTR CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 KCNB2 LEPROTL1 NSF NXF1 OCIAD1 OPRM1 OSBP RB1CC1 RETREG3 RMDN2 RMDN3 SCN3B SEC11C SIK1 SLC16A7 SLC18A1 SLC35B1 SNX2 STARD3 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 USP40 VAMP1 VAMP2 ZBTB22
Entrez ID		4905	9218
HPRD ID		03380	09299
Ensembl ID		ENSG00000073969	ENSG00000101558
Uniprot IDs		A0A384MTI6 P46459	Q9P0L0
PDB IDs		6KZQ	2RR3 6TQR
Enriched GO Terms of Interacting Partners?		Membrane Fusion SNARE Complex Intracellular Protein Localization SNARE Binding Protein Transport Organelle Localization By Membrane Tethering Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Membrane Docking SNAP Receptor Activity Vesicle Fusion Establishment Of Protein Localization Chemical Synaptic Transmission Organelle Membrane Fusion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled GABA Receptor Activity G Protein-coupled GABA Receptor Complex G Protein-coupled Receptor Heterodimeric Complex Organelle Fusion Intracellular Protein Transport Vesicle Docking Positive Regulation Of Synaptic Transmission Dendritic Spine Regulation Of Protein Localization To Cell Periphery GABA Receptor Complex Golgi Vesicle Transport Soluble NSF Attachment Protein Activity Regulation Of Protein Localization To Membrane Membrane Organization Negative Regulation Of Dopamine Secretion Vesicle Organization Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Modulation Of Chemical Synaptic Transmission Intracellular Transport Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling Regulation Of Catecholamine Secretion Negative Regulation Of Synaptic Transmission Establishment Of Localization In Cell GABA Receptor Activity AMPA Glutamate Receptor Activity Postsynaptic Membrane Regulation Of Protein Localization To Plasma Membrane ATP-dependent Protein Binding Chloride Channel Inhibitor Activity Synaptic Transmission, Glutamatergic Cell-cell Signaling Syntaxin Binding Endomembrane System	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Ascorbate Homeostasis Clathrin-coated Endocytic Vesicle Membrane Protein Localization To Cell Periphery Transmembrane Monodehydroascorbate Reductase Activity Regulation Of Cellular Localization Organic Hydroxy Compound Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Regulation Of Establishment Of Protein Localization Cellular Localization Endosome Establishment Of Localization In Cell Regulation Of Protein Localization Regulation Of Protein Transport Transmembrane Transport Monoatomic Ion Transport Protein Localization To Membrane Protein Localization To Plasma Membrane ERBB2-EGFR Signaling Pathway Potassium Channel Regulator Activity Negative Regulation Of Protein Transport Syntaxin Binding Monoatomic Ion Channel Complex Organelle Membrane Contact Site Cytoplasmic Vesicle SNARE Complex Assembly Inorganic Ion Transmembrane Transport Localization Within Membrane Negative Regulation Of Establishment Of Protein Localization Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Hormone Secretion Regulation Of Protein Secretion SNARE Binding Regulation Of Transport Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Monoatomic Ion Transmembrane Transport Monoatomic Cation Transport Cholesterol Transport Regulation Of Secretion By Cell Vesicle-mediated Transport Endosome Membrane Metal Ion Transport Negative Regulation Of Protein Secretion Syntaxin-1 Binding Protein Binding Regulation Of Insulin Secretion Inorganic Cation Transmembrane Transport
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