NSF and STX8

Number of citations of the paper that reports this interaction (PMID 10683148)
10

Data Source:
HPRD (in vivo)

		NSF	STX8
Gene Name		N-ethylmaleimide-sensitive factor	syntaxin 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Lysosomal Membrane Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft Extracellular Vesicular Exosome	Lysosomal Membrane Endosome Early Endosome Late Endosome Endoplasmic Reticulum Trans-Golgi Network Integral Component Of Plasma Membrane SNARE Complex Late Endosome Membrane Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Rab GTPase Binding Protein Kinase Binding PDZ Domain Binding Protein Complex Binding ATPase Activity, Coupled Metal Ion Binding	SNAP Receptor Activity Chloride Channel Inhibitor Activity Syntaxin Binding Ubiquitin Protein Ligase Binding
	Biological Process	Positive Regulation Of Receptor Recycling Potassium Ion Transport Exocytosis Intra-Golgi Vesicle-mediated Transport Synaptic Transmission Vesicle-mediated Transport Regulation Of Exocytosis Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Golgi Vesicle Docking	Transport Intracellular Protein Transport Vesicle Fusion Endosome To Lysosome Transport Early Endosome To Late Endosome Transport Regulation Of Protein Localization To Plasma Membrane
Pathways		Trafficking of GluR2-containing AMPA receptors Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Parkinson's disease ( 19915575 21812969)
Protein-Protein Interactions		25 interactors: ARRB1 C14orf1 CD28 DRD2 EIF3E FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 KIAA1377 LUC7L2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA	17 interactors: ACVR1 CALM1 CLN8 COPA CREB3 NAPA NAPG NSF STX1A STX4 STX7 TGFBR1 UBC VPS11 VPS18 VTI1B WDR91
Entrez ID		4905	9482
HPRD ID		03380	05012
Ensembl ID		ENSG00000073969
Uniprot IDs		P46459	Q9UNK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Fusion Membrane Organization Intracellular Transport Golgi Vesicle Transport Protein Localization Establishment Of Localization In Cell Protein Transport Synaptic Transmission Vesicle-mediated Transport Establishment Of Protein Localization Cellular Localization Cell-cell Signaling Intracellular Protein Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Cellular Protein Localization Neuron-neuron Synaptic Transmission Organelle Fusion Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Vesicle Organization Negative Regulation Of CAMP Biosynthetic Process Transport Mitochondrion Degradation Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Organelle Disassembly Synaptic Transmission, Glutamatergic Receptor Internalization Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Adenylate Cyclase Activity Regulation Of Vesicle-mediated Transport Regulation Of Cyclase Activity Regulation Of Insulin Secretion Synaptic Vesicle Fusion To Presynaptic Membrane Cytoplasmic Transport Regulation Of Cellular Localization G-protein Coupled Receptor Internalization Regulation Of Peptide Hormone Secretion Cellular Component Assembly Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Receptor Metabolic Process Vesicle Docking Post-Golgi Vesicle-mediated Transport Regulation Of CAMP Biosynthetic Process Membrane Docking Regulation Of Protein Localization Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway	Membrane Organization Membrane Fusion Vesicle Docking Membrane Docking Intracellular Protein Transport Cellular Localization Cellular Protein Localization Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Regulation Of Cellular Localization Golgi Vesicle Transport Vesicle Fusion Intra-Golgi Vesicle-mediated Transport Exocytosis Secretion Organelle Fusion Vesicle Organization Post-Golgi Vesicle-mediated Transport Transport Secretion By Cell Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Regulation Of Synaptic Vesicle Priming Regulation Of Protein Localization To Plasma Membrane Regulation Of Protein Localization Vesicle Docking Involved In Exocytosis Regulation Of Cellular Component Organization Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Pharyngeal System Development Positive Regulation Of Transport Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Neurotransmitter Levels Organelle Localization Activin Receptor Signaling Pathway Neurotransmitter Transport Regulation Of Synaptic Vesicle Exocytosis Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Apoptotic Process Cell-cell Signaling Negative Regulation Of Apoptotic Process Response To Transforming Growth Factor Beta
Tagcloud ?		acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 snap snare snares syntaxin thought verified vesicles	cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic nsf perforin snap snare snares stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp3 vamp4 vesicle vti1b
Tagcloud (Difference) ?		acetate alkylating amount apical associate attachment bound caco cellubrevin coimmunoprecipitation colocalizes connection define docking epithelium ethylmaleimide munc myristate phorbol predominantly quantity sec1 syntaxin thought verified vesicles	cd3 ctls eliminate exocytosis granules granzymes groundwork laying lgs lytic perforin stx13 stx16 stx3 stx4 stx6 stx7 synapse synapses syntaxin1b2 tumorigenic vamp3 vamp4 vesicle vti1b
Tagcloud (Intersection) ?		nsf snap snare snares