HERC1 and LAPTM5

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		HERC1	LAPTM5
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	lysosomal protein transmembrane 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane	Lysosome Lysosomal Membrane Integral Component Of Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity ARF Guanyl-nucleotide Exchange Factor Activity Ligase Activity
	Biological Process	Transport Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Neuron Projection Development Positive Regulation Of GTPase Activity Neuromuscular Process Controlling Balance	Transport
Pathways
Drugs
Diseases
GWAS		Iris characteristics ( 21835309)
Protein-Protein Interactions		7 interactors: BAK1 EP300 LAPTM5 PKM RNF11 SOX9 UBE2D3	25 interactors: ANKRD13A DCUN1D1 DISP1 EPN1 EPN2 EPN3 EPS15 HERC1 HEY1 HEYL HUWE1 ITCH KRT7 LDLRAD1 NEDD4 NEDD4L RNF168 SMURF2 TNFAIP3 TOM1L2 UBA52 UBAC1 UBC USP13 WWP1
Entrez ID		8925	7805
HPRD ID		06894	03280
Ensembl ID		ENSG00000103657	ENSG00000162511
Uniprot IDs		Q15751	Q13571 Q5TBB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Endocrine Pancreas Development Programmed Cell Death Regulation Of DNA-templated Transcription In Response To Stress Cell Death Death Response To Abiotic Stimulus Cellular Response To Mechanical Stimulus Negative Regulation Of Gene Expression Histone H2B Acetylation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Primary Prostatic Bud Elongation Retinal Rod Cell Differentiation Fibroblast Apoptotic Process Camera-type Eye Morphogenesis Regulation Of Protein Binding Tube Development B Cell Negative Selection N-terminal Peptidyl-lysine Acetylation Renal Vesicle Induction Male Germ-line Sex Determination Response To Endoplasmic Reticulum Stress Eye Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Metanephric Nephron Tubule Formation Intestinal Epithelial Structure Maintenance Intrahepatic Bile Duct Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Positive Regulation Of Mesenchymal Stem Cell Differentiation Primary Sex Determination Response To Mycotoxin Astrocyte Fate Commitment Post-embryonic Camera-type Eye Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation Limb Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Tubulin Deacetylation Regulation Of Extracellular Matrix Assembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Notch Signaling Pathway Protein Catabolic Process Negative Regulation Of Signal Transduction Cellular Macromolecule Catabolic Process Negative Regulation Of Signaling Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Proteolysis Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein Monoubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Protein Modification Process Viral Life Cycle Regulation Of ERBB Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of Gene Expression Regulation Of Signal Transduction Negative Regulation Of Biosynthetic Process Catabolic Process Cellular Response To Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Regulation Of Signaling Cell Surface Receptor Signaling Pathway Signal Transduction
Tagcloud ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase subclonal unfavourable warranted wt1 zrsr2	bioinformatics cd53 coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome transesterification
Tagcloud (Intersection) ?		splicing