HERC1 and BAK1

Number of citations of the paper that reports this interaction (PMID 25408501)
0

Data Source:
BioGRID (unspecified method)

		HERC1	BAK1
Gene Name		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	BCL2-antagonist/killer 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane	Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Cytosol Integral Component Of Mitochondrial Outer Membrane Pore Complex
	Molecular Function	Ubiquitin-protein Transferase Activity ARF Guanyl-nucleotide Exchange Factor Activity Ligase Activity	Protein Binding Heat Shock Protein Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Chaperone Binding BH Domain Binding
	Biological Process	Transport Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Neuron Projection Development Positive Regulation Of GTPase Activity Neuromuscular Process Controlling Balance	B Cell Homeostasis B Cell Apoptotic Process Release Of Cytochrome C From Mitochondria Blood Vessel Remodeling Myeloid Cell Homeostasis B Cell Negative Selection Apoptotic Process Brain Development Aging Mitochondrial Fusion Cell Proliferation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Response To Fungus Response To Mycotoxin Response To UV-C Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Response To Gamma Radiation Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Endocrine Pancreas Development Organ Regeneration Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Negative Regulation Of Peptidyl-serine Phosphorylation Cellular Response To UV Limb Morphogenesis Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Regulation Of Protein Homodimerization Activity Regulation Of Protein Heterodimerization Activity Fibroblast Apoptotic Process Response To Ethanol Positive Regulation Of Proteolysis Regulation Of Mitochondrial Membrane Permeability Post-embryonic Camera-type Eye Morphogenesis Regulation Of Cell Cycle Regulation Of Mitochondrial Membrane Potential Vagina Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Thymocyte Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of Release Of Cytochrome C From Mitochondria Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Apoptotic Process Involved In Patterning Of Blood Vessels
Pathways			Programmed Cell Death Activation and oligomerization of BAK protein Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Iris characteristics ( 21835309)	Chronic lymphocytic leukemia ( 22700719) Hematological parameters ( 19820697) Mean platelet volume ( 22423221) Obesity-related traits ( 23251661) Platelet counts ( 22139419 23263863 20139978) Testicular germ cell tumor ( 19483681 23666239 23666240)
Protein-Protein Interactions		7 interactors: BAK1 EP300 LAPTM5 PKM RNF11 SOX9 UBE2D3	19 interactors: ARHGDIA BAX BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BID DBN1 ERN1 HERC1 HSD17B4 HSPD1 MCL1 MFN1 NFKBIB TP53 VDAC1 VDAC2
Entrez ID		8925	578
HPRD ID		06894	02744
Ensembl ID		ENSG00000103657	ENSG00000030110
Uniprot IDs		Q15751	Q16611
PDB IDs			1BXL 2IMS 2IMT 2JBY 2JCN 2M5B 2XPX 2YV6 3I1H 3QBR
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Endocrine Pancreas Development Programmed Cell Death Regulation Of DNA-templated Transcription In Response To Stress Cell Death Death Response To Abiotic Stimulus Cellular Response To Mechanical Stimulus Negative Regulation Of Gene Expression Histone H2B Acetylation Regulation Of Cell Proliferation Involved In Tissue Homeostasis Epithelial Cell Proliferation Involved In Prostatic Bud Elongation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Regulation Of Type I Interferon Production Cellular Response To Oxygen Levels Primary Prostatic Bud Elongation Retinal Rod Cell Differentiation Fibroblast Apoptotic Process Camera-type Eye Morphogenesis Regulation Of Protein Binding Tube Development B Cell Negative Selection N-terminal Peptidyl-lysine Acetylation Renal Vesicle Induction Male Germ-line Sex Determination Response To Endoplasmic Reticulum Stress Eye Morphogenesis Positive Regulation Of Extracellular Matrix Assembly Metanephric Nephron Tubule Formation Intestinal Epithelial Structure Maintenance Intrahepatic Bile Duct Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Positive Regulation Of Mesenchymal Stem Cell Differentiation Primary Sex Determination Response To Mycotoxin Astrocyte Fate Commitment Post-embryonic Camera-type Eye Morphogenesis Negative Regulation Of Photoreceptor Cell Differentiation Limb Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Intrinsic Apoptotic Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Tubulin Deacetylation Regulation Of Extracellular Matrix Assembly Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response	Regulation Of Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Extrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Apoptotic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Programmed Cell Death Cell Death Death Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Apoptotic Process Regulation Of Cell Death Neuron Apoptotic Process Mitochondrial Membrane Organization Neuron Death Cellular Response To DNA Damage Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrion Organization Positive Regulation Of Cell Death Mitochondrion Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Intracellular Signal Transduction Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Cell Proliferation Regulation Of Signaling Negative Regulation Of Signal Transduction Response To Gamma Radiation Cellular Response To Stress Male Gonad Development Negative Regulation Of Signaling Mitochondrial Transport Positive Regulation Of Mitochondrion Organization Response To Stress
Tagcloud ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		bcl11b cadherin discovered dnm2 druggable exhibitedthe fat1 fbxw7 frequencies guide harboured jak jak3 lymphoblastic mll2 mutational notch1 notch2 phf6 recurrent regulators reln secretase splicing subclonal unfavourable warranted wt1 zrsr2	akt1 antipsychotic atg atg12 atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?