FHIT

Name	fragile histidine triad diadenosine triphosphatase
Structure
Novel Interactors	1 novel interactors: CADPS
Interactors	13 interactors: BCAS2 CTNNB1 DDIT4L FDXR GSN HSPD1 PRPF6 RAB40B REL SRC TRIM23 UBE2I YTHDF1
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Adenosine 5'-monophosphoramidase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Adenylylsulfatase Activity Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Purine Nucleotide Metabolic Process Apoptotic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Drugs	Adenosine monotungstate Ado-P-Ch2-P-Ps-Ado
Diseases	Small cell lung cancer Non-small cell lung cancer
GWAS	Adult body size ( 32376654 ) Adverse response to lamotrigine and phenytoin ( 22379998 ) Age at first sexual intercourse ( 34211149 ) Aortic root size ( 21223598 ) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598 ) Asperger disorder ( 21182207 ) Attention deficit hyperactivity disorder ( 18821565 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blood pressure ( 24954895 ) Blood protein levels ( 30072576 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 28892062 28552196 28448500 26961502 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Broad depression or schizophrenia ( 30626913 ) Bronchopulmonary dysplasia ( 23897914 ) Caudal anterior-cingulate cortex volume ( 31530798 ) Cognitive function ( 25644384 ) Conotruncal heart defects ( 24800985 ) Depressive symptom measurement or major depressive disorder ( 28049566 ) Differentiated thyroid cancer ( 28703219 ) Falling risk ( 32999390 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Hip circumference ( 28552196 ) Intracranial aneurysm ( 29531279 ) Iris color (L* coordinate) ( 30895295 ) Irritable bowel syndrome ( 29673008 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lung function (maximal voluntary ventilation) ( 29095316 ) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643 ) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643 ) Major depressive disorder ( 20125088 ) Methadone dose in opioid dependence ( 28115739 ) Myopia (pathological) ( 23049088 ) Orofacial clefts ( 22419666 ) Papillary thyroid cancer ( 28703219 ) Pars triangularis volume ( 31530798 ) Photic sneeze reflex ( 27182965 ) Postoperative myocardial infarction after cardiac surgery ( 30678657 ) Refractive error ( 32231278 ) Response to amphetamines ( 22952603 ) Response to citalopram treatment ( 22760553 ) Schizophrenia ( 30285260 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Waist circumference ( 28552196 ) Weight ( 28552196 )
Entrez ID	2272
HPRD ID	03096
Ensembl ID	ENSG00000189283
Uniprot IDs	P49789
PDB IDs	1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT 7P8P
GO Terms Enriched among Interactors ?	Bone Resorption Response To Muscle Stretch Oocyte Development Cellular Component Assembly Regulation Of Podosome Assembly Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Post-translational Protein Modification Immune System Process Protein Metabolic Process Germ Cell Development Lamellipodium Enzyme Binding Glial Cell Fate Determination Transcription Coregulator Binding Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Ferredoxin-NADP+ Reductase Activity Response To Cytokine Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Podosome Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Oogenesis Regulation Of Lamellipodium Organization SUMO Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Response To Peptide Regulation Of Protein Processing Protein Destabilization Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Epidermal Growth Factor Receptor Signaling Pathway Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Protein Catabolic Process Forebrain Development Regulation Of Protein Maturation Positive Regulation Of Protein Processing In Phagocytic Vesicle Female Gamete Generation Protein Modification By Small Protein Conjugation