FHIT and HSPD1

Number of citations: 22 (PubMedID 19004824)
Data Source: HPRD (in vitro)

		FHIT	HSPD1
Name		fragile histidine triad diadenosine triphosphatase	heat shock protein family D (Hsp60) member 1
Structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane	Extracellular Space Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Early Endosome Cytosol Plasma Membrane Clathrin-coated Pit Cell Surface Membrane Coated Vesicle Secretory Granule Protein-containing Complex Intracellular Membrane-bounded Organelle Lipopolysaccharide Receptor Complex Extracellular Exosome Sperm Midpiece Sperm Plasma Membrane Migrasome
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Transferase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Adenosine 5'-monophosphoramidase Activity Adenylylsulfate-ammonia Adenylyltransferase Activity Adenylylsulfatase Activity Bis(5'-adenosyl)-triphosphatase Activity	Nucleotide Binding Lipopolysaccharide Binding P53 Binding DNA Replication Origin Binding Single-stranded DNA Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding High-density Lipoprotein Particle Binding Isomerase Activity ATP Hydrolysis Activity Enzyme Binding Ubiquitin Protein Ligase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Unfolded Protein Binding Protein-folding Chaperone Binding Cysteine-type Endopeptidase Activator Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Purine Nucleotide Metabolic Process Apoptotic Process Diadenosine Triphosphate Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Positive Regulation Of Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Protein Folding 'de Novo' Protein Folding Response To Unfolded Protein Apoptotic Mitochondrial Changes Response To Cold Positive Regulation Of Interferon-alpha Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Mitochondrial Unfolded Protein Response Protein Refolding B Cell Proliferation T Cell Activation B Cell Activation Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Adhesion Of Symbiont To Host Protein Import Into Mitochondrial Intermembrane Space Isotype Switching To IgG Isotypes Protein Stabilization Positive Regulation Of T Cell Activation Chaperone-mediated Protein Complex Assembly Protein Maturation Biological Process Involved In Interaction With Symbiont Cellular Response To Interleukin-7 Negative Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Execution Phase Of Apoptosis
Pathways		None	Mitochondrial protein import Mitochondrial protein import TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation Mitochondrial protein degradation Mitochondrial unfolded protein response (UPRmt)
Drugs		Adenosine monotungstate Ado-P-Ch2-P-Ps-Ado	Copper
Diseases		Small cell lung cancer Non-small cell lung cancer	Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD) Hereditary spastic paraplegia (SPG)
GWAS		Adult body size ( 32376654 ) Adverse response to lamotrigine and phenytoin ( 22379998 ) Age at first sexual intercourse ( 34211149 ) Aortic root size ( 21223598 ) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598 ) Asperger disorder ( 21182207 ) Attention deficit hyperactivity disorder ( 18821565 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Blood pressure ( 24954895 ) Blood protein levels ( 30072576 ) BMI (adjusted for smoking behaviour) ( 28443625 ) BMI in non-smokers ( 28443625 ) BMI in smokers ( 28443625 ) Body mass index ( 28892062 28552196 28448500 26961502 25673413 ) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500 ) Body mass index (joint analysis main effects and smoking interaction) ( 28443625 ) Body mass index in physically active individuals ( 28448500 ) Body size at age 10 ( 32376654 ) Broad depression or schizophrenia ( 30626913 ) Bronchopulmonary dysplasia ( 23897914 ) Caudal anterior-cingulate cortex volume ( 31530798 ) Cognitive function ( 25644384 ) Conotruncal heart defects ( 24800985 ) Depressive symptom measurement or major depressive disorder ( 28049566 ) Differentiated thyroid cancer ( 28703219 ) Falling risk ( 32999390 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535 ) Hip circumference ( 28552196 ) Intracranial aneurysm ( 29531279 ) Iris color (L* coordinate) ( 30895295 ) Irritable bowel syndrome ( 29673008 ) L1-L4 bone mineral density x serum urate levels interaction ( 34046847 ) Lung function (maximal voluntary ventilation) ( 29095316 ) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643 ) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643 ) Major depressive disorder ( 20125088 ) Methadone dose in opioid dependence ( 28115739 ) Myopia (pathological) ( 23049088 ) Orofacial clefts ( 22419666 ) Papillary thyroid cancer ( 28703219 ) Pars triangularis volume ( 31530798 ) Photic sneeze reflex ( 27182965 ) Postoperative myocardial infarction after cardiac surgery ( 30678657 ) Refractive error ( 32231278 ) Response to amphetamines ( 22952603 ) Response to citalopram treatment ( 22760553 ) Schizophrenia ( 30285260 ) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189 ) Urinary metabolite levels in chronic kidney disease ( 29545352 ) Waist circumference ( 28552196 ) Weight ( 28552196 )	Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Schizophrenia ( 25056061 29483656 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 )
Novel Interactors		1 novel interactors: CADPS	6 novel interactors: CASP6 GLI2 KCTD10 MGAT3 MOB4 SF3B1
Interacting Genes		13 interacting genes: BCAS2 CTNNB1 DDIT4L FDXR GSN HSPD1 PRPF6 RAB40B REL SRC TRIM23 UBE2I YTHDF1	58 interacting genes: ALDH2 APP BAK1 BRCA1 CA2 CASP3 CASP9 CEP70 CFTR CLEC7A CLU CYSRT1 DHFR DUX4 ERBB2 ERG FAM107A FHIT FNDC3B H2BC21 HSPE1 ITGA3 ITGB1 KRT31 KRT34 KRT40 KRTAP10-3 KRTAP10-8 KRTAP5-9 LINC01554 LRRK2 LZTS2 MAPK6 MCPH1 NOS1AP NOTCH2NLA NR3C1 OGT PDE4B PLCG2 PLG PPP2R1A PPP2R1B PRKACA PRNP PTEN PTPN11 RASA1 RGS20 SAMD3 SUMO2 SUMO4 SUPT6H TLR1 TMCC2 TRIM63 UBASH3A YWHAG
Entrez ID		2272	3329
HPRD ID		03096	00318
Ensembl ID		ENSG00000189283	ENSG00000144381
Uniprot IDs		P49789	A0A024R3X4 P10809
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT 7P8P	4PJ1 6HT7 6MRC 6MRD 7AZP 7L7S 8G7J 8G7K 8G7L 8G7M 8G7N 8G7O 8U39
GO Terms Enriched among Interactors		Bone Resorption Response To Muscle Stretch Oocyte Development Cellular Component Assembly Regulation Of Podosome Assembly Positive Regulation Of Protein Processing Positive Regulation Of Protein Maturation Post-translational Protein Modification Immune System Process Protein Metabolic Process Germ Cell Development Lamellipodium Enzyme Binding Glial Cell Fate Determination Transcription Coregulator Binding Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Ferredoxin-NADP+ Reductase Activity Response To Cytokine Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Podosome Mitochondrial Unfolded Protein Response Isotype Switching To IgG Isotypes Oogenesis Regulation Of Lamellipodium Organization SUMO Conjugating Enzyme Activity Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Response To Peptide Regulation Of Protein Processing Protein Destabilization Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Epidermal Growth Factor Receptor Signaling Pathway Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Protein Catabolic Process Forebrain Development Regulation Of Protein Maturation Positive Regulation Of Protein Processing In Phagocytic Vesicle Female Gamete Generation Protein Modification By Small Protein Conjugation	Protein-folding Chaperone Binding Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Signaling Cytosol Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Cell Communication Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of Programmed Cell Death Regulation Of Signal Transduction Signal Transduction Regulation Of Proteolysis Regulation Of Calcium-mediated Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Calcium-mediated Signaling Negative Regulation Of Cell Adhesion Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Positive Regulation Of Cell Communication Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Signaling Identical Protein Binding Negative Regulation Of Intracellular Signal Transduction Regulation Of Interleukin-2 Production Protein Heterodimerization Activity Regulation Of Protein Localization Glutamatergic Synapse Response To Stress Regulation Of Cytokine Production Fibroblast Apoptotic Process Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Proteolysis Regulation Of Reactive Oxygen Species Metabolic Process Integrin Alpha3-beta1 Complex Membrane Raft Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Calcium Ion Transmembrane Transport Neuron Projection Organization Regulation Of Programmed Cell Death Response To Yeast Cognition Regulation Of Cellular Localization Keratin Filament Regulation Of Multicellular Organismal Process