FHIT and UBE2I

Number of citations of the paper that reports this interaction (PMID 11085938)
5

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		FHIT	UBE2I
Gene Name		fragile histidine triad	ubiquitin-conjugating enzyme E2I
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Synaptonemal Complex Fibrillar Center Nucleus Nucleoplasm Cytoplasm PML Body Dendrite Synapse Transferase Complex Sumoylated E2 Ligase Complex
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity	Protein Binding ATP Binding Protein C-terminus Binding Transcription Factor Binding Ligase Activity Enzyme Binding Ubiquitin Protein Ligase Binding HLH Domain Binding BHLH Transcription Factor Binding Poly(A) RNA Binding Ubiquitin Protein Ligase Activity SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding
	Biological Process	Purine Nucleotide Metabolic Process DNA Replication Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Mitotic Nuclear Division Regulation Of Receptor Activity Viral Process Protein Ubiquitination Protein Sumoylation Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Division Positive Regulation Of SUMO Transferase Activity
Pathways			Post-translational protein modification SUMOylation Meiotic synapsis Processing and activation of SUMO SUMO is transferred from E1 to E2 (UBE2I, UBC9)
Drugs		Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Major depressive disorder ( 20125088) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553)
Protein-Protein Interactions		9 interactors: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I	258 interactors: ADAR ANXA1 APEX1 AR ARNT ARNTL ATF2 ATF7IP ATXN1 BCAM BEND5 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CDC37 CDCA8 CEBPD CEBPE CFTR CHD3 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 DACH1 DAXX DES DHX9 DNM1 DNMT3A DNMT3B DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV6 EXOSC9 FAS FHIT FHL3 FLI1 FMR1 FOS FOXM1 GCM1 GLUL GMCL1P1 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIPK1 HIPK2 HIPK3 HIST1H4A HIST4H4 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HSF1 HSF2 HSF2BP IKZF1 IKZF3 IPO13 JUN KCNK1 KCTD1 KLHL12 KRT19 LMNA LMO2 LNX2 MAP3K1 MAPK1IP1L MARCH5 MDM2 MED7 MGRN1 MITF MKL1 MKRN3 MTA1 MYB NCOR2 NIN NR1D2 NR1H2 NR3C1 NR3C2 NR5A2 NUDCD3 PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PLAGL1 PML PPARA PPARGC1A PPM1J PRKAA2 PRPF40A PSMC3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RC3H2 RCBTB2 RFPL3 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPS6KA6 SAE1 SALL1 SATB1 SCNN1A SETBP1 SETD8 SETDB1 SETX SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SMAD4 SNIP1 SOCS6 SOX10 SOX4 SP100 SP3 SPECC1L SREBF1 SREBF2 SRF STAT1 STRA13 SUMO1 SUMO1P1 SUMO2 SUMO3 SUZ12 TAB2 TAF1 TAF10 TAF12 TAF5 TBP TCF3 TCF7L2 TDG TDP2 TFAP2A TFAP2B TFAP2C TNFRSF1A TOP1 TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRPS1 UBA2 UBE2K UBXN1 UCHL1 UNC119 USP25 WHSC1L1 WT1 XBP1 XIAP ZBED1 ZBTB16 ZBTB26 ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF451 ZNF646 ZNRD1
Entrez ID		2272	7329
HPRD ID		03096	09045
Ensembl ID		ENSG00000189283	ENSG00000103275
Uniprot IDs		A8K1A9 P49789 Q45QG9	A8K503 B0QYN7 P63279
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT	1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Protein Complex Assembly Regulation Of Cytokine Production Viral Process Regulation Of Cell Adhesion Bone Resorption Osteoclast Differentiation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Activation Positive Regulation Of Cellular Component Biogenesis Response To Cadmium Ion Bone Remodeling Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Interleukin-12 Production Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Apoptotic Process Negative Regulation Of Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lymphocyte Activation Programmed Cell Death Execution Phase Of Apoptosis Oogenesis Positive Regulation Of Type I Interferon Production Protein Complex Assembly Positive Regulation Of Organelle Organization B Cell Cytokine Production Isotype Switching To IgG Isotypes Positive Regulation Of SUMO Transferase Activity Cell Death Death Adherens Junction Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Activation Response To Inorganic Substance Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Female Gamete Generation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Progesterone Stimulus	Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription From RNA Polymerase II Promoter Biosynthetic Process Regulation Of Cellular Process Protein Ubiquitination Chromosome Organization Response To Organic Substance Metabolic Process Cellular Protein Modification Process Cellular Response To Stress Chromatin Organization Chromatin Modification Peptidyl-lysine Modification Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Response To Stimulus
Tagcloud ?			array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?			array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2e1 ube2n ube2q1 ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?