FHIT and FDXR

Number of citations of the paper that reports this interaction (PMID 19004824)
5

Data Source:
HPRD (in vitro)

		FHIT	FDXR
Gene Name		fragile histidine triad	ferredoxin reductase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity	Ferredoxin-NADP+ Reductase Activity Protein Binding NADPH-adrenodoxin Reductase Activity
	Biological Process	Purine Nucleotide Metabolic Process DNA Replication Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Generation Of Precursor Metabolites And Energy Steroid Biosynthetic Process C21-steroid Hormone Biosynthetic Process Ubiquinone Biosynthetic Process Xenobiotic Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Sterol Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolism of lipids and lipoproteins Pregnenolone biosynthesis Mitochondrial iron-sulfur cluster biogenesis Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Electron transport from NADPH to Ferredoxin Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type Endogenous sterols Biological oxidations Defective FMO3 causes Trimethylaminuria (TMAU) Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Metabolism of steroid hormones and vitamin D Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs		Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Major depressive disorder ( 20125088) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553)
Protein-Protein Interactions		9 interactors: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I	3 interactors: FDX1 FHIT POU2F1
Entrez ID		2272	2232
HPRD ID		03096	00060
Ensembl ID		ENSG00000189283	ENSG00000161513
Uniprot IDs		A8K1A9 P49789 Q45QG9	P22570 Q6GSK2
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Protein Complex Assembly Regulation Of Cytokine Production Viral Process Regulation Of Cell Adhesion Bone Resorption Osteoclast Differentiation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Activation Positive Regulation Of Cellular Component Biogenesis Response To Cadmium Ion Bone Remodeling Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Interleukin-12 Production Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Apoptotic Process Negative Regulation Of Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lymphocyte Activation Programmed Cell Death Execution Phase Of Apoptosis Oogenesis Positive Regulation Of Type I Interferon Production Protein Complex Assembly Positive Regulation Of Organelle Organization B Cell Cytokine Production Isotype Switching To IgG Isotypes Positive Regulation Of SUMO Transferase Activity Cell Death Death Adherens Junction Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Activation Response To Inorganic Substance Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Female Gamete Generation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Progesterone Stimulus	Olfactory Placode Formation Lens Induction In Camera-type Eye
Tagcloud ?			biomarker ccng1 cis constructed curves ddb2 documented dose doses estimate evident fit fulfill gy individual inter ionizing irradiated linear mgy polynomial proportionality ranges reproducibility requirements responsive transcriptionally variability variation
Tagcloud (Difference) ?			biomarker ccng1 cis constructed curves ddb2 documented dose doses estimate evident fit fulfill gy individual inter ionizing irradiated linear mgy polynomial proportionality ranges reproducibility requirements responsive transcriptionally variability variation
Tagcloud (Intersection) ?