FHIT and GSN

Number of citations of the paper that reports this interaction (PMID 12833632)
2

Data Source:
HPRD (in vitro)

		FHIT	GSN
Gene Name		fragile histidine triad	gelsolin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Ruffle Extracellular Region Cytosol Focal Adhesion Actin Cytoskeleton Lamellipodium Protein Complex Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity	Actin Binding Calcium Ion Binding Protein Binding
	Biological Process	Purine Nucleotide Metabolic Process DNA Replication Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Aging Oligodendrocyte Development Vesicle-mediated Transport Actin Filament Polymerization Regulation Of Cell Adhesion Tissue Regeneration Actin Nucleation Response To Ethanol Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Response To Folic Acid Cilium Morphogenesis Cellular Response To Cadmium Ion
Pathways			Amyloids Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Major depressive disorder ( 20125088) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553)
Protein-Protein Interactions		9 interactors: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I	23 interactors: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1
Entrez ID		2272	2934
HPRD ID		03096	00674
Ensembl ID		ENSG00000189283	ENSG00000148180
Uniprot IDs		A8K1A9 P49789 Q45QG9	B7Z4U6 B7Z5V1 F5H1A8 P06396
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Protein Complex Assembly Regulation Of Cytokine Production Viral Process Regulation Of Cell Adhesion Bone Resorption Osteoclast Differentiation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Activation Positive Regulation Of Cellular Component Biogenesis Response To Cadmium Ion Bone Remodeling Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Interleukin-12 Production Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Apoptotic Process Negative Regulation Of Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lymphocyte Activation Programmed Cell Death Execution Phase Of Apoptosis Oogenesis Positive Regulation Of Type I Interferon Production Protein Complex Assembly Positive Regulation Of Organelle Organization B Cell Cytokine Production Isotype Switching To IgG Isotypes Positive Regulation Of SUMO Transferase Activity Cell Death Death Adherens Junction Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Activation Response To Inorganic Substance Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Female Gamete Generation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Progesterone Stimulus	Platelet Activation Blood Coagulation Hemostasis Cell Junction Assembly Response To Wounding Regulation Of Body Fluid Levels Wound Healing Adherens Junction Organization Movement Of Cell Or Subcellular Component Cell Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell-cell Junction Organization Response To Stimulus Response To Stress Anatomical Structure Morphogenesis Neurogenesis Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cell Morphogenesis Regulation Of Kinase Activity Cell Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Cell Differentiation Cellular Component Assembly Cell Projection Organization Signaling Anatomical Structure Development Generation Of Neurons Platelet Aggregation Cell Communication Positive Regulation Of Protein Metabolic Process Locomotion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Kinase Activity Signal Transduction Positive Regulation Of Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Nervous System Development Developmental Process Multicellular Organismal Development Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation System Development Regulation Of Cellular Component Organization Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity
Tagcloud ?			amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield
Tagcloud (Difference) ?			amyloidogenic amyloidosis autosomal contractility counter crossbreeding dermatological disturbed dominantly folding furin g2 g654a gelsolin generates hampered hereditary inherited mt1 nanobodies nanobody nb11 ophthalmological proteases proteolysis proteolytic rendering secreting shield
Tagcloud (Intersection) ?