FHIT and RAB40B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FHIT	RAB40B
Gene Name		fragile histidine triad	RAB40B, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Plasma Membrane Endosome Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity	GTPase Activity GTP Binding GDP Binding
	Biological Process	Purine Nucleotide Metabolic Process DNA Replication Transcription, DNA-templated Regulation Of Transcription, DNA-templated Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Protein Ubiquitination Regulation Of Exocytosis Rab Protein Signal Transduction Protein Localization To Plasma Membrane
Pathways
Drugs		Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Major depressive disorder ( 20125088) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553)
Protein-Protein Interactions		9 interactors: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I	3 interactors: APP FHIT WFDC1
Entrez ID		2272	10966
HPRD ID		03096	11472
Ensembl ID		ENSG00000189283
Uniprot IDs		A8K1A9 P49789 Q45QG9	Q12829
PDB IDs		1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cytokine Production Positive Regulation Of Protein Complex Assembly Regulation Of Cytokine Production Viral Process Regulation Of Cell Adhesion Bone Resorption Osteoclast Differentiation Positive Regulation Of Interleukin-12 Production Regulation Of T Cell Activation Positive Regulation Of Cellular Component Biogenesis Response To Cadmium Ion Bone Remodeling Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Protein Complex Assembly Cellular Protein Complex Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cellular Response To Stimulus Regulation Of Interleukin-12 Production Regulation Of Cell-cell Adhesion Intracellular Signal Transduction Apoptotic Process Negative Regulation Of Cell Death Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Lymphocyte Activation Programmed Cell Death Execution Phase Of Apoptosis Oogenesis Positive Regulation Of Type I Interferon Production Protein Complex Assembly Positive Regulation Of Organelle Organization B Cell Cytokine Production Isotype Switching To IgG Isotypes Positive Regulation Of SUMO Transferase Activity Cell Death Death Adherens Junction Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Cell Activation Response To Inorganic Substance Signal Transduction Regulation Of Type I Interferon Production Positive Regulation Of Protein Metabolic Process Female Gamete Generation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Cellular Response To Progesterone Stimulus	Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Protein Processing Regulation Of Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Cellular Protein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Cellular Metabolic Process Regulation Of Endopeptidase Activity Axon Choice Point Recognition Regulation Of Protein Metabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Peptidase Activity Neuron Remodeling Regulation Of Growth Cellular Copper Ion Homeostasis Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Catalytic Activity Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis RNA Polyadenylation Neuron Recognition Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Programmed Cell Death Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Death Death Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Positive Regulation Of Mitotic Cell Cycle Phase Transition Neuron Apoptotic Process Positive Regulation Of Cell Cycle Phase Transition Regulation Of Protein Tyrosine Kinase Activity
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