TFIP11 and SMARCE1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid, two hybrid)

		TFIP11	SMARCE1
Description		tuftelin interacting protein 11	SWI/SNF related BAF chromatin remodeling complex subunit E1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome	Nuclear Chromosome Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Protein-containing Complex Brahma Complex NpBAF Complex NBAF Complex BBAF Complex
	Molecular Function	Nucleic Acid Binding Protein Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Binding N-acetyltransferase Activity Nuclear Receptor Binding Nucleosomal DNA Binding
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Neurogenesis Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair
Pathways		mRNA Splicing - Major Pathway	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)
Drugs			Phenethyl Isothiocyanate
Diseases
GWAS			Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 30929738 31619474 31959851) Asthma (childhood onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Triglyceride levels in HIV infection ( 33109212)
Interacting Genes		270 interacting genes: AARD ABI2 ABLIM3 AIMP2 AIRIM ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAG4 BAZ2B BCAS2 BCL6 BHLHA9 BICD2 BMF BRD1 BYSL CARD9 CATSPERT CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP55 CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CPEB2 CPSF7 CT55 CWF19L2 DAXX DDX25 DES DGCR6 DHX16 DISC1 DPPA3 DSCAM DTNB EAF2 EIF3A EIF3D ENKD1 ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 EXOSC7 EXOSC8 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GNL3L GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF20A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNA LMNB2 LMO1 LMO2 LMO4 LNX1 LSP1P3 LYSMD1 MAB21L2 MAGOH MCM7 MDM2 MED1 METTL17 MFAP1 MKRN3 MRPL11 MTCL2 MTFR2 MYO15B MYO1D MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 NXF1 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 PSMA4 PSMC5 PSTPIP1 PTCD1 RBBP6 RBM22 RBM7 RCOR3 RHNO1 RIN1 RNF10 RNF6 RPL23A RPUSD3 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SF1 SFPQ SFR1 SGF29 SH2D4A SH3GLB1 SHANK3 SMARCB1 SMARCE1 SNAPIN SNRNP48 SNRPA SNRPB SNRPN SNW1 SNX20 SNX32 SPG21 SSX2IP STRA8 STRN SUGP1 SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 THOC1 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSC1 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 UNKL USP2 USP6 USP7 UTP14A UTP6 VPS37C VPS39 WAC WASHC3 WBP4 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12	94 interacting genes: AMOTL2 AR ARID2 BAZ1B BRAP BRMS1 CCDC136 CCDC172 CCDC183 CCHCR1 CDR2 CEBPA CEP170P1 CEP63 CEP70 CYSRT1 DISC1 EPS8 ERG ESR1 ESR2 EXOC4 EXOC7 FAM217B FSD2 GATA1 GOLGA2 GOLGA6L9 GRIPAP1 HUNK IFT74 IFT88 ING5 ITCH JAKMIP2 KIFC3 KLF1 KRT14 KRT15 KRT16 KRT19 KRT27 KRT31 KRT34 KRT35 KRT37 KRT39 KRT40 KRTAP1-1 KRTAP10-8 KRTAP10-9 KRTAP6-3 MDM2 MED4 MEOX2 MIPOL1 MRFAP1L1 MTUS2 NBPF22P NCOA1 NCOA2 NCOA3 NOTCH2NLA NR0B2 NR3C1 NUP62 OGT OIP5 PGR PSMC6 RALBP1 RARB RCOR1 RELB RINT1 RSPH1 SIN3A SIN3B SMAD1 SMARCA4 SPAG5 SRC STX11 SYCE1 TEX12 TFE3 TFIP11 TIAM1 TNIK TRIM54 TRIP10 TXLNA USHBP1 VPS52
Entrez ID		24144	6605
HPRD ID		11628	04382
Ensembl ID		ENSG00000100109	ENSG00000073584
Uniprot IDs		Q9UBB9	Q969G3
PDB IDs		8RO2	6LTH 6LTJ 7CYU 7VDV 7Y8R
Enriched GO Terms of Interacting Partners?		Protein Binding Centrosome Cytoskeleton Spliceosomal Complex Microtubule-based Process Nucleoplasm Nucleus MRNA Metabolic Process MRNA Processing Microtubule Cytoskeleton Organization MRNA Splicing, Via Spliceosome Cytoskeleton Organization Nuclear Speck RNA Splicing, Via Transesterification Reactions RNA Splicing Organelle Organization RNA Processing RNA Metabolic Process Cytoplasm Microtubule Organizing Center Organization Nucleic Acid Metabolic Process Centriole Nucleolus U4/U6 X U5 Tri-snRNP Complex SnRNP Binding Cilium Organization Cellular Component Assembly Identical Protein Binding Microtubule Regulation Of Vitamin D Receptor Signaling Pathway U2-type Precatalytic Spliceosome Microtubule Binding General Transcription Initiation Factor Binding Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Nuclear Matrix Macromolecule Metabolic Process Chromatin Organization Kinesin Complex Exoribonuclease Complex Centrosome Cycle Intermediate Filament Cytoskeleton Epigenetic Regulation Of Gene Expression P53 Binding DNA-binding Transcription Factor Binding Intermediate Filament Organization Microtubule-based Movement Structural Constituent Of Cytoskeleton U4 SnRNA 3'-end Processing Intermediate Filament	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Nuclear Receptor-mediated Signaling Pathway Morphogenesis Of An Epithelium Cytoskeleton Tissue Morphogenesis Estrogen Response Element Binding Chromatin Structural Molecule Activity Protein Binding Intracellular Receptor Signaling Pathway Cytoskeleton Organization Organelle Organization Hormone-mediated Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Binding Steroid Binding Nuclear Receptor Activity Supramolecular Fiber Organization Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Epithelial Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Signal Transduction Anatomical Structure Morphogenesis Cellular Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Steroid Receptor Activity Sin3-type Complex Estrogen Receptor Signaling Pathway Positive Regulation Of Stem Cell Population Maintenance Cytosol Positive Regulation Of RNA Metabolic Process Epidermis Development Cell Differentiation DNA-binding Transcription Factor Activity Protein-containing Complex Cellular Response To Hormone Stimulus Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Developmental Process Transcription Repressor Complex Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process
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