TFIP11 and WAC

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFIP11	WAC
Description		tuftelin interacting protein 11	WW domain containing adaptor with coiled-coil
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Nucleic Acid Binding Protein Binding	RNA Polymerase II Complex Binding Chromatin Binding Protein Binding
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Chromatin Organization Chromatin Remodeling DNA Damage Response Regulation Of Autophagy Positive Regulation Of Macroautophagy Mitotic G1 DNA Damage Checkpoint Signaling Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of TORC1 Signaling
Pathways		mRNA Splicing - Major Pathway	E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Diastolic blood pressure ( 30224653) Intraocular pressure ( 29617998) Liver enzyme levels (alkaline phosphatase) ( 33972514) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple myeloma ( 27363682)
Interacting Genes		270 interacting genes: AARD ABI2 ABLIM3 AIMP2 AIRIM ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAG4 BAZ2B BCAS2 BCL6 BHLHA9 BICD2 BMF BRD1 BYSL CARD9 CATSPERT CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP55 CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CPEB2 CPSF7 CT55 CWF19L2 DAXX DDX25 DES DGCR6 DHX16 DISC1 DPPA3 DSCAM DTNB EAF2 EIF3A EIF3D ENKD1 ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 EXOSC7 EXOSC8 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GNL3L GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF20A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNA LMNB2 LMO1 LMO2 LMO4 LNX1 LSP1P3 LYSMD1 MAB21L2 MAGOH MCM7 MDM2 MED1 METTL17 MFAP1 MKRN3 MRPL11 MTCL2 MTFR2 MYO15B MYO1D MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 NXF1 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 PSMA4 PSMC5 PSTPIP1 PTCD1 RBBP6 RBM22 RBM7 RCOR3 RHNO1 RIN1 RNF10 RNF6 RPL23A RPUSD3 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SF1 SFPQ SFR1 SGF29 SH2D4A SH3GLB1 SHANK3 SMARCB1 SMARCE1 SNAPIN SNRNP48 SNRPA SNRPB SNRPN SNW1 SNX20 SNX32 SPG21 SSX2IP STRA8 STRN SUGP1 SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 THOC1 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSC1 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 UNKL USP2 USP6 USP7 UTP14A UTP6 VPS37C VPS39 WAC WASHC3 WBP4 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12	29 interacting genes: AKAP9 APP BACH1 CCDC6 CDC37 CDK1 CRKL DYDC1 HMG20B KLC3 KRT15 LNX1 MOBP MTUS2 NDE1 NFE2L2 PLK1 SYTL5 TFIP11 TNS2 TRAF1 TRAF3IP1 TRAF3IP3 TTC3 UBC UBQLN4 VCP VCPIP1 ZDHHC17
Entrez ID		24144	51322
HPRD ID		11628	18291
Ensembl ID		ENSG00000100109	ENSG00000095787
Uniprot IDs		Q9UBB9	Q9BTA9
PDB IDs		8RO2
Enriched GO Terms of Interacting Partners?		Protein Binding Centrosome Cytoskeleton Spliceosomal Complex Microtubule-based Process Nucleoplasm Nucleus MRNA Metabolic Process MRNA Processing Microtubule Cytoskeleton Organization MRNA Splicing, Via Spliceosome Cytoskeleton Organization Nuclear Speck RNA Splicing, Via Transesterification Reactions RNA Splicing Organelle Organization RNA Processing RNA Metabolic Process Cytoplasm Microtubule Organizing Center Organization Nucleic Acid Metabolic Process Centriole Nucleolus U4/U6 X U5 Tri-snRNP Complex SnRNP Binding Cilium Organization Cellular Component Assembly Identical Protein Binding Microtubule Regulation Of Vitamin D Receptor Signaling Pathway U2-type Precatalytic Spliceosome Microtubule Binding General Transcription Initiation Factor Binding Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Nuclear Matrix Macromolecule Metabolic Process Chromatin Organization Kinesin Complex Exoribonuclease Complex Centrosome Cycle Intermediate Filament Cytoskeleton Epigenetic Regulation Of Gene Expression P53 Binding DNA-binding Transcription Factor Binding Intermediate Filament Organization Microtubule-based Movement Structural Constituent Of Cytoskeleton U4 SnRNA 3'-end Processing Intermediate Filament	Cytoplasm Post-translational Protein Modification Protein Modification By Small Protein Conjugation Response To Copper Ion Microtubule-based Process Identical Protein Binding Protein Modification Process Centrosome Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Protein Ubiquitination Microtubule Binding Negative Regulation Of DNA Repair Negative Regulation Of Double-strand Break Repair Protein-DNA Covalent Cross-linking Repair Regulation Of Protein Localization To Chromatin K48-linked Polyubiquitin Modification-dependent Protein Binding Mitotic Nuclear Membrane Disassembly DNA Metabolic Process DNA Repair Centrosome Separation Transport Along Microtubule Regulation Of Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Nuclear Membrane Disassembly Cytoskeleton-dependent Intracellular Transport Membrane Disassembly Modification-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Microtubule Organizing Center Organization Positive Regulation Of Protein Catabolic Process Regulation Of Proteolysis Protein Metabolic Process Microtubule-based Transport Cellular Response To Copper Ion Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Microtubule Cytoskeleton Organization Protein Localization To Site Of Double-strand Break Protein Binding Positive Regulation Of Proteasomal Protein Catabolic Process Golgi Organization Cytoskeleton Organization Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Superoxide Metabolic Process Amyloid-beta Complex Regulation Of Cellular Component Organization Growth Cone Lamellipodium
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