TFIP11 and RIN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TFIP11	RIN1
Description		tuftelin interacting protein 11	Ras and Rab interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Endocytic Vesicle
	Molecular Function	Nucleic Acid Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Endocytosis Signal Transduction Vesicle-mediated Transport Intracellular Signal Transduction
Pathways		mRNA Splicing - Major Pathway	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972 31043756)
Interacting Genes		270 interacting genes: AARD ABI2 ABLIM3 AIMP2 AIRIM ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAG4 BAZ2B BCAS2 BCL6 BHLHA9 BICD2 BMF BRD1 BYSL CARD9 CATSPERT CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP55 CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CPEB2 CPSF7 CT55 CWF19L2 DAXX DDX25 DES DGCR6 DHX16 DISC1 DPPA3 DSCAM DTNB EAF2 EIF3A EIF3D ENKD1 ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 EXOSC7 EXOSC8 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GNL3L GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF20A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNA LMNB2 LMO1 LMO2 LMO4 LNX1 LSP1P3 LYSMD1 MAB21L2 MAGOH MCM7 MDM2 MED1 METTL17 MFAP1 MKRN3 MRPL11 MTCL2 MTFR2 MYO15B MYO1D MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 NXF1 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRC1 PRPF18 PRPF31 PRPF6 PSMA4 PSMC5 PSTPIP1 PTCD1 RBBP6 RBM22 RBM7 RCOR3 RHNO1 RIN1 RNF10 RNF6 RPL23A RPUSD3 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SF1 SFPQ SFR1 SGF29 SH2D4A SH3GLB1 SHANK3 SMARCB1 SMARCE1 SNAPIN SNRNP48 SNRPA SNRPB SNRPN SNW1 SNX20 SNX32 SPG21 SSX2IP STRA8 STRN SUGP1 SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 THOC1 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSC1 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 UNKL USP2 USP6 USP7 UTP14A UTP6 VPS37C VPS39 WAC WASHC3 WBP4 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12	49 interacting genes: ABL1 ABL2 AFDN ANKS1A ANKS1B CALCOCO2 CAPNS2 CARD10 CRACR2B EGFR EIF3F ERBB2 ERBB3 GOLGA2 GOLGA6L9 HMG20A HRAS HSF2BP ITSN1 KLHL12 KRT34 KRTAP13-1 KRTAP15-1 LZTS2 MDFI MTDH PICK1 PLEKHG4 RAB5A RAB5B RALGDS RRAS2 SEC23B SH3RF1 SNX17 SORBS3 SPRED1 TBC1D1 TFIP11 TRAF2 TRIM23 TRIM27 TRIM7 TRIP10 TSC1 YWHAB YWHAE YWHAZ ZBED1
Entrez ID		24144	9610
HPRD ID		11628	05813
Ensembl ID		ENSG00000100109	ENSG00000174791
Uniprot IDs		Q9UBB9	A0A0S2Z4T5 A0A0S2Z4U0 Q13671
PDB IDs		8RO2
Enriched GO Terms of Interacting Partners?		Protein Binding Centrosome Cytoskeleton Spliceosomal Complex Microtubule-based Process Nucleoplasm Nucleus MRNA Metabolic Process MRNA Processing Microtubule Cytoskeleton Organization MRNA Splicing, Via Spliceosome Cytoskeleton Organization Nuclear Speck RNA Splicing, Via Transesterification Reactions RNA Splicing Organelle Organization RNA Processing RNA Metabolic Process Cytoplasm Microtubule Organizing Center Organization Nucleic Acid Metabolic Process Centriole Nucleolus U4/U6 X U5 Tri-snRNP Complex SnRNP Binding Cilium Organization Cellular Component Assembly Identical Protein Binding Microtubule Regulation Of Vitamin D Receptor Signaling Pathway U2-type Precatalytic Spliceosome Microtubule Binding General Transcription Initiation Factor Binding Microtubule Anchoring Microtubule Anchoring At Microtubule Organizing Center Nuclear Matrix Macromolecule Metabolic Process Chromatin Organization Kinesin Complex Exoribonuclease Complex Centrosome Cycle Intermediate Filament Cytoskeleton Epigenetic Regulation Of Gene Expression P53 Binding DNA-binding Transcription Factor Binding Intermediate Filament Organization Microtubule-based Movement Structural Constituent Of Cytoskeleton U4 SnRNA 3'-end Processing Intermediate Filament	Cytosol Cytoplasm Perinuclear Region Of Cytoplasm Phosphoserine Residue Binding Epidermal Growth Factor Receptor Signaling Pathway Regulation Of MAPK Cascade ERBB Signaling Pathway GDP Binding Intracellular Signaling Cassette MAPK Cascade Identical Protein Binding Regulation Of Intracellular Signal Transduction Protein Sequestering Activity ERBB3:ERBB2 Complex Regulation Of Autophagy Melanosome Positive Regulation Of Intracellular Signal Transduction Cellular Localization Vesicle-mediated Transport Schwann Cell Development Protein Tyrosine Kinase Activity Glial Cell Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of MAPK Cascade Establishment Of Protein Localization Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Binding Establishment Of Localization In Cell Regulation Of Cell Communication Signal Transduction Regulation Of Signaling ErbB-3 Class Receptor Binding Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Actin Filament-based Process Protein Binding Regulation Of Establishment Of T Cell Polarity Regulation Of Signal Transduction Protein Modification Process Regulation Of Fibroblast Proliferation Regulation Of ERK1 And ERK2 Cascade Protein Phosphatase Binding Myelination Axon Ensheathment Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERBB2-EGFR Signaling Pathway
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