ALOX5AP and ALOX5

Number of citations of the paper that reports this interaction (PMID 9445303)
20

Data Source:
HPRD (in vivo)

		ALOX5AP	ALOX5
Gene Name		arachidonate 5-lipoxygenase-activating protein	arachidonate 5-lipoxygenase
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Extracellular Space Nuclear Envelope Nuclear Envelope Lumen Cytosol Nuclear Matrix Nuclear Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding	Arachidonate 5-lipoxygenase Activity Iron Ion Binding Protein Binding
	Biological Process	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Protein Homotrimerization Cellular Response To Calcium Ion Lipoxin Metabolic Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)	Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs			Vitamin E Masoprocol Aminosalicylic Acid Mesalazine Montelukast Diclofenac Diethylcarbamazine Zileuton Sulfasalazine Meclofenamic acid Balsalazide Minocycline Hyperforin Heme
Diseases
GWAS		Non-word repetition ( 23738518)	Mean corpuscular hemoglobin ( 20139978) Mean corpuscular volume ( 20139978)
Protein-Protein Interactions		3 interactors: ALOX5 CLIC1 LTC4S	17 interactors: ACTB ALOX5AP APP CEP57L1 CEP63 COTL1 DICER1 GRB2 HHIPL2 LTC4S MAD1L1 MAPKAPK2 MEOX1 NUTM1 REL SYCE1 TGFBRAP1
Entrez ID		241	240
HPRD ID		04742	01065
Ensembl ID		ENSG00000132965	ENSG00000012779
Uniprot IDs		P20292	E5FPY5 E5FPY8 P09917
PDB IDs		2Q7M 2Q7R	2ABV 3O8Y 3V92 3V98 3V99
Enriched GO Terms of Interacting Partners?		Lipoxin Metabolic Process Lipoxygenase Pathway Leukotriene Biosynthetic Process Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Leukotriene Production Involved In Inflammatory Response Fatty Acid Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Mitochondrial Membrane Potential Cellular Lipid Metabolic Process Platelet Aggregation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Lipid Metabolic Process Positive Regulation Of Osteoblast Differentiation Oxidation-reduction Process Positive Regulation Of Ossification Chloride Transmembrane Transport Regulation Of Osteoblast Differentiation Chloride Transport	Leukotriene Metabolic Process Lipoxin Metabolic Process Arachidonic Acid Metabolic Process Defense Response Lipoxygenase Pathway Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Leukotriene Biosynthetic Process Cellular Component Assembly MRNA Stabilization Innate Immune Response Cell Division Immune System Process Platelet Activation Cell Cycle Process Cell Cycle Checkpoint Icosanoid Biosynthetic Process Wound Healing Regulation Of MRNA Stability Unsaturated Fatty Acid Biosynthetic Process Regulation Of RNA Stability Neuron Projection Morphogenesis Conversion Of Ds SiRNA To Ss SiRNA Involved In RNA Interference Regulation Of Metaphase Plate Congression Hair Follicle Cell Proliferation Conversion Of Ds SiRNA To Ss SiRNA Positive Regulation Of Metabolic Process Response To External Stimulus Endocytosis Response To Stress Response To Wounding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Fatty Acid Metabolic Process Immune Response Microtubule-based Process Regulation Of ERBB Signaling Pathway Regulation Of Enamel Mineralization Peripheral Nervous System Myelin Formation Synaptic Growth At Neuromuscular Junction Zygote Asymmetric Cell Division Spindle Assembly Cell Cycle Neuron Projection Development Signal Transduction In Response To DNA Damage Cell Projection Morphogenesis Vesicle-mediated Transport Targeting Of MRNA For Destruction Involved In RNA Interference Collateral Sprouting In Absence Of Injury Axon Guidance
Tagcloud ?		acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin	af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage lipoxygenase mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Difference) ?		acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin	af4 calcitriol conversely deacetylase derivatives deriving elongation encodes hdac hdac1 hdaci inactive lineage mll overwrites physiologically portion relieving smad3 smad4 surprisingly switch transcriptionally transforming trichostatin trimethylation tsa
Tagcloud (Intersection) ?		lipoxygenase