ALOX5AP and LTC4S

Number of citations of the paper that reports this interaction (PMID 19233132)
1

Data Source:
BioGRID (pull down)

		ALOX5AP	LTC4S
Gene Name		arachidonate 5-lipoxygenase-activating protein	leukotriene C4 synthase
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding
	Biological Process	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Protein Homotrimerization Cellular Response To Calcium Ion Lipoxin Metabolic Process	Leukotriene Metabolic Process Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Small Molecule Metabolic Process Oxidation-reduction Process Lipoxin Metabolic Process
Pathways		Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)	Arachidonic acid metabolism Synthesis of 5-eicosatetraenoic acids Metabolism of lipids and lipoproteins Synthesis of Lipoxins (LX) Synthesis of Leukotrienes (LT) and Eoxins (EX)
Drugs			Glutathione
Diseases
GWAS		Non-word repetition ( 23738518)
Protein-Protein Interactions		3 interactors: ALOX5 CLIC1 LTC4S	3 interactors: ALOX5 ALOX5AP MGST1
Entrez ID		241	4056
HPRD ID		04742	02004
Ensembl ID		ENSG00000132965	ENSG00000213316
Uniprot IDs		P20292	Q16873
PDB IDs		2Q7M 2Q7R	2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV
Enriched GO Terms of Interacting Partners?		Lipoxin Metabolic Process Lipoxygenase Pathway Leukotriene Biosynthetic Process Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Leukotriene Production Involved In Inflammatory Response Fatty Acid Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Production Of Molecular Mediator Involved In Inflammatory Response Regulation Of Mitochondrial Membrane Potential Cellular Lipid Metabolic Process Platelet Aggregation Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Lipid Metabolic Process Positive Regulation Of Osteoblast Differentiation Oxidation-reduction Process Positive Regulation Of Ossification Chloride Transmembrane Transport Regulation Of Osteoblast Differentiation Chloride Transport	Lipoxin Metabolic Process Lipoxygenase Pathway Protein Homotrimerization Leukotriene Biosynthetic Process Protein Trimerization Leukotriene Metabolic Process Icosanoid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Arachidonic Acid Metabolic Process Icosanoid Metabolic Process Unsaturated Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Cellular Response To Lipid Hydroperoxide Leukotriene Production Involved In Inflammatory Response Protein Homooligomerization Response To Lipid Hydroperoxide Fatty Acid Metabolic Process Protein Oligomerization Small Molecule Metabolic Process Lipid Biosynthetic Process Monocarboxylic Acid Metabolic Process Cellular Response To Hydroperoxide Leydig Cell Differentiation Response To Hydroperoxide Glutathione Derivative Biosynthetic Process Production Of Molecular Mediator Involved In Inflammatory Response Cellular Lipid Metabolic Process Protein Complex Assembly Carboxylic Acid Metabolic Process Cellular Response To Calcium Ion Organic Acid Metabolic Process Lipid Metabolic Process Biosynthetic Process Glutathione Metabolic Process Oxidation-reduction Process Response To Calcium Ion Cellular Response To Metal Ion Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Cellular Response To Inorganic Substance Cellular Component Assembly Response To Xenobiotic Stimulus Peptide Metabolic Process Male Gonad Development Male Sex Differentiation Cellular Response To Oxidative Stress Gonad Development Development Of Primary Sexual Characteristics Cellular Modified Amino Acid Metabolic Process
Tagcloud ?		acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin	apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b
Tagcloud (Difference) ?		acat acyltransferase arachidonate ath atherosclerotic cbs cysthathionenine deceased gathered genomelab gexp hcats irs1 lcat ldlr lecithin lipoxygenase lpl malaysian metallopeptidase methylenetetrahydrofolate mmp9 mortem mthfr ncat predetermined tgfbr2 thbd thrombomodulin	apcdd1 attributable beadchip clec2d dox doxycycline efnb1 il1rn illumina interrogate ocil ogn opg osteoblast osteoclastogenesis osteoclastogenic paid pluripotent profiled rspo2 runx2 rx2 sema3a sema7a slco2b1 splenocytes st2 tnc tnfrsf11b
Tagcloud (Intersection) ?