ALOX5AP and SLC29A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ALOX5AP	SLC29A2
Description		arachidonate 5-lipoxygenase activating protein	solute carrier family 29 member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Nucleolus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Arachidonate Binding	Neurotransmitter Transmembrane Transporter Activity Nucleoside Transmembrane Transporter Activity Nucleobase Transmembrane Transporter Activity Adenine Transmembrane Transporter Activity Guanine Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Purine Nucleoside Transmembrane Transporter Activity Cytidine Transmembrane Transporter Activity Uridine Transmembrane Transporter Activity
	Biological Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Leukotriene Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Neurotransmitter Uptake Neurotransmitter Transport Xenobiotic Transmembrane Transport Nucleobase Transport Adenine Transport Guanine Transport Nucleoside Transport Purine Nucleoside Transmembrane Transport Cytidine Transport Uridine Transmembrane Transport Adenosine Transport Inosine Transport Hypoxanthine Transport Thymine Transport Pyrimidine-containing Compound Transmembrane Transport Transport Across Blood-brain Barrier Nucleoside Transmembrane Transport Guanine Transmembrane Transport Uracil Transmembrane Transport Purine Nucleobase Transmembrane Transport
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX)	Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane Azathioprine ADME
Drugs		DG031 AM103 Fiboflapon Veliflapon MK-886	Ethanol
Diseases
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)	Bipolar disorder ( 21926972) Serum metabolite levels ( 33031748) Serum uric acid levels ( 32514006)
Interacting Genes		10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	19 interacting genes: ALOX5AP CERS3 CERS4 CREB3 ERGIC3 GJA4 GPR152 LAPTM4B PLPP5 SERINC2 SLC10A1 SLC10A6 TMEM237 TMEM242 TMEM33 TMEM86B TMX2 UBQLN1 UBQLN2
Entrez ID		241	3177
HPRD ID		04742	03662
Ensembl ID		ENSG00000132965	ENSG00000174669
Uniprot IDs		A0A087WW23 P20292	Q14542 Q96FB2
PDB IDs		2Q7M 2Q7R 6VGC 6VGI
Enriched GO Terms of Interacting Partners?		Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Biosynthetic Process Leukocyte Chemotaxis Leukotriene Metabolic Process Cell Chemotaxis Regulation Of Protein Secretion Long-chain Fatty Acid Biosynthetic Process Leukocyte Migration Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Nuclear Membrane Negative Regulation Of Endothelial Cell Proliferation Membrane Icosanoid Biosynthetic Process Nitrate Transmembrane Transporter Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Metformin Leukotriene A4 Metabolic Process Locomotion Leukotriene Production Involved In Inflammatory Response Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Positive Regulation Of Developmental Process Arachidonate 12(S)-lipoxygenase Activity Chemotaxis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Protein Secretion Uracil Transmembrane Transport Thymine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Cellular Response To Morphine Soluble NSF Attachment Protein Activity SNARE Complex Disassembly	Membrane Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Endoplasmic Reticulum Bile Acid:sodium Symporter Activity Positive Regulation Of Response To Endoplasmic Reticulum Stress Sphingosine N-acyltransferase Activity Response To Endoplasmic Reticulum Stress Positive Regulation Of ERAD Pathway Bile Acid And Bile Salt Transport Regulation Of ERAD Pathway Positive Regulation Of Deacetylase Activity Polyubiquitin Modification-dependent Protein Binding Negative Regulation Of Store-operated Calcium Channel Activity D-lysine 5,6-aminomutase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Leukotriene Production Involved In Inflammatory Response Regulation Of Vacuole Organization Negative Regulation Of G Protein-coupled Receptor Internalization Retrograde Transporter Complex, Golgi To ER Regulation Of Lysosomal Membrane Permeability Ceramide Biosynthetic Process Ether Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
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