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ALOX5AP
Description
arachidonate 5-lipoxygenase activating protein
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Nuclear Membrane
Molecular Function
Glutathione Transferase Activity
Leukotriene-C4 Synthase Activity
Glutathione Peroxidase Activity
Protein Binding
Enzyme Activator Activity
Arachidonate Binding
Biological Process
Leukotriene Production Involved In Inflammatory Response
Leukotriene Metabolic Process
Leukotriene Biosynthetic Process
Carboxylic Acid Biosynthetic Process
Protein Homotrimerization
Cellular Response To Calcium Ion
Cellular Oxidant Detoxification
Pathways
Synthesis of 5-eicosatetraenoic acids
Synthesis of Leukotrienes (LT) and Eoxins (EX)
Biosynthesis of Lipoxins (LX)
Drugs
DG031
AM103
Fiboflapon
Veliflapon
MK-886
Diseases
GWAS
Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) (
24025145
)
General risk tolerance (MTAG) (
30643258
)
Non-word repetition (
23738518
)
Novel Interacting Genes
2 novel interacting genes:
FLT1
GDF15
Interacting Genes
10 interacting genes:
ALOX5
AQP6
CLIC1
FFAR2
GPR42
LTC4S
NAPB
OPRM1
SLC29A2
TMEM120B
Entrez ID
241
HPRD ID
04742
Ensembl ID
ENSG00000132965
Uniprot IDs
A0A087WW23
P20292
PDB IDs
2Q7M
2Q7R
6VGC
6VGI
Enriched GO Terms of Interacting Partners
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Leukocyte Chemotaxis Involved In Inflammatory Response
Leukocyte Migration Involved In Inflammatory Response
Leukotriene Biosynthetic Process
Leukocyte Chemotaxis
Leukotriene Metabolic Process
Cell Chemotaxis
Regulation Of Protein Secretion
Long-chain Fatty Acid Biosynthetic Process
Leukocyte Migration
Leukotriene A4 Biosynthetic Process
Arachidonate 5-lipoxygenase Activity
Nuclear Envelope
Nuclear Membrane
Negative Regulation Of Endothelial Cell Proliferation
Membrane
Icosanoid Biosynthetic Process
Nitrate Transmembrane Transporter Activity
Placental Growth Factor Receptor Activity
Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway
Morphine Receptor Activity
Negative Regulation Of Wnt Protein Secretion
Beta-endorphin Receptor Activity
Response To Metformin
Leukotriene A4 Metabolic Process
Locomotion
Leukotriene Production Involved In Inflammatory Response
Long-chain Fatty Acid Metabolic Process
Icosanoid Metabolic Process
Arachidonate 8(S)-lipoxygenase Activity
Lipoxin Biosynthetic Process
Positive Regulation Of Developmental Process
Arachidonate 12(S)-lipoxygenase Activity
Chemotaxis
Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
PH-gated Chloride Channel Activity
Nitrate Transmembrane Transport
Chloride Transmembrane Transport
G Protein-coupled Receptor Activity
Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus
Negative Regulation Of Protein Secretion
Uracil Transmembrane Transport
Thymine Transport
Pyrimidine Nucleobase Transmembrane Transport
Nucleobase Transmembrane Transporter Activity
Uracil Transmembrane Transporter Activity
Hypoxanthine Transport
Purine Nucleoside Transmembrane Transporter Activity
Cellular Response To Morphine
Soluble NSF Attachment Protein Activity
SNARE Complex Disassembly
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