ALOX5AP and GDF15

Data Source: HiPPIP (Novel)

		ALOX5AP	GDF15
Name		arachidonate 5-lipoxygenase activating protein	growth differentiation factor 15
Structure
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Apparatus Extracellular Matrix Extracellular Exosome
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Arachidonate Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity
	Biological Process	Leukotriene Production Involved In Inflammatory Response Leukotriene Metabolic Process Leukotriene Biosynthetic Process Carboxylic Acid Biosynthetic Process Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification	Reduction Of Food Intake In Response To Dietary Excess Negative Regulation Of Leukocyte Migration Signal Transduction Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Cell-cell Signaling Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Appetite Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Cellular Response To Chemical Stress Energy Homeostasis GDF15-GFRAL Signaling Pathway Response To Metformin Positive Regulation Of Myoblast Fusion
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX)	None
Drugs		DG031 AM103 Fiboflapon Veliflapon MK-886	None
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145 ) General risk tolerance (MTAG) ( 30643258 ) Non-word repetition ( 23738518 )	Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Coffee consumption ( 31046077 ) Growth differentiation factor-15 levels ( 29628937 ) Hyperemesis gravidarum ( 29563502 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Severity of nausea and vomiting of pregnancy ( 29563502 )
Novel Interactors		2 novel interactors: FLT1 GDF15	13 novel interactors: ALOX5AP BORCS8-MEF2B BRME1 COPE EHF FCHO1 HOMER3 IL27RA MAST3 MED26 PDE4C SIN3B SULT2A1
Interacting Genes		10 interacting genes: ALOX5 AQP6 CLIC1 FFAR2 GPR42 LTC4S NAPB OPRM1 SLC29A2 TMEM120B	7 interacting genes: CBX3 HOXA1 KRTAP12-2 MAPK14 MDFI NLGN3 TACC3
Entrez ID		241	9518
HPRD ID		04742	05608
Ensembl ID		ENSG00000132965	ENSG00000130513
Uniprot IDs		A0A087WW23 P20292	Q99988
PDB IDs		2Q7M 2Q7R 6VGC 6VGI	5VT2 5VZ3 5VZ4 6Q2J
GO Terms Enriched among Interactors		Leukocyte Chemotaxis Involved In Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Leukotriene Biosynthetic Process Leukocyte Chemotaxis Leukotriene Metabolic Process Cell Chemotaxis Regulation Of Protein Secretion Long-chain Fatty Acid Biosynthetic Process Leukocyte Migration Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Nuclear Membrane Negative Regulation Of Endothelial Cell Proliferation Membrane Icosanoid Biosynthetic Process Nitrate Transmembrane Transporter Activity Placental Growth Factor Receptor Activity Vascular Endothelial Growth Factor Receptor-1 Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Metformin Leukotriene A4 Metabolic Process Locomotion Leukotriene Production Involved In Inflammatory Response Long-chain Fatty Acid Metabolic Process Icosanoid Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Lipoxin Biosynthetic Process Positive Regulation Of Developmental Process Arachidonate 12(S)-lipoxygenase Activity Chemotaxis Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell PH-gated Chloride Channel Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport G Protein-coupled Receptor Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Protein Secretion Uracil Transmembrane Transport Thymine Transport Pyrimidine Nucleobase Transmembrane Transport Nucleobase Transmembrane Transporter Activity Uracil Transmembrane Transporter Activity Hypoxanthine Transport Purine Nucleoside Transmembrane Transporter Activity Cellular Response To Morphine Soluble NSF Attachment Protein Activity SNARE Complex Disassembly	None