BRD1 and H2AFX

Number of citations of the paper that reports this interaction (PMID 20224553)
36

Data Source:
BioGRID (pull down)

		BRD1	H2AFX
Gene Name		bromodomain containing 1	H2A histone family, member X
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex	Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Site Of Double-strand Break Extracellular Vesicular Exosome
	Molecular Function	Zinc Ion Binding Histone Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Histone H3 Acetylation	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Nucleosome Assembly Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Positive Regulation Of DNA Repair Meiotic Cell Cycle
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways Deposition of new CENPA-containing nucleosomes at the centromere Cellular Senescence Signaling by Wnt Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends RNF mutants show enhanced WNT signaling and proliferation Homologous recombination repair of replication-independent double-strand breaks ATM mediated phosphorylation of repair proteins DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance ATM mediated response to DNA double-strand break misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Chromatin organization formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Senescence-Associated Secretory Phenotype (SASP) Chromatin modifying enzymes Recruitment of repair and signaling proteins to double-strand breaks SIRT1 negatively regulates rRNA Expression Condensation of Prophase Chromosomes MRN complex relocalizes to nuclear foci RNA Polymerase I Promoter Clearance Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks M Phase Telomere Maintenance Nucleosome assembly XAV939 inhibits tankyrase, stabilizing AXIN Double-Strand Break Repair DNA methylation Transcriptional regulation by small RNAs Meiotic recombination RNA Polymerase I Transcription Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Cell Cycle, Mitotic PRC2 methylates histones and DNA RMTs methylate histone arginines TCF dependent signaling in response to WNT Oxidative Stress Induced Senescence Homologous Recombination Repair RNA Polymerase I Promoter Opening Signaling by WNT in cancer
Drugs
Diseases
GWAS		Natriuretic peptide levels ( 21273288) Schizophrenia ( 23894747)
Protein-Protein Interactions		9 interactors: FEZ1 FEZ2 H2AFX H3F3A HIST2H3C KIAA1377 SS18L1 VIM ZNF512B	45 interactors: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 KAT5 MASP1 MCPH1 MDC1 MRE11A NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PPP2R4 PRKDC QARS RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TSSK6 WRN XRCC6
Entrez ID		23774	3014
HPRD ID		06848	03465
Ensembl ID		ENSG00000100425	ENSG00000188486
Uniprot IDs		J3KNX6 O95696	P16104
PDB IDs		2KU3 2L43 2LQ6 3LYI 3RCW	2D31 2DYP 3SHV 3SQD 3SZM 3U3Z
Enriched GO Terms of Interacting Partners?		DNA Methylation On Cytosine Chromatin Silencing At RDNA Chromatin Silencing DNA Methylation Regulation Of Neuron Projection Development Regulation Of Dendrite Morphogenesis Negative Regulation Of Gene Expression, Epigenetic DNA Modification Cell Projection Organization Regulation Of Cell Projection Organization Gene Silencing Regulation Of Dendrite Development Regulation Of Neuron Differentiation Nucleosome Assembly Chromatin Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Protein-DNA Complex Assembly Generation Of Neurons Regulation Of Neurogenesis Chromatin Organization DNA Packaging Neurogenesis Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Bergmann Glial Cell Differentiation Neuron Projection Development Positive Regulation Of Neuron Projection Development Cell Development Heterocycle Metabolic Process Cell Projection Morphogenesis Cellular Aromatic Compound Metabolic Process Organelle Organization Regulation Of Cell Development Cell Part Morphogenesis Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Component Organization Cellular Nitrogen Compound Metabolic Process Neuron Development DNA Conformation Change Positive Regulation Of Cell Projection Organization Gene Expression Negative Regulation Of Macroautophagy Chromosome Organization Regulation Of Metabolic Process Cell Morphogenesis DNA Metabolic Process Establishment Of Mitochondrion Localization Positive Regulation Of Neuron Differentiation	DNA Metabolic Process Double-strand Break Repair DNA Repair Cellular Response To DNA Damage Stimulus Chromosome Organization DNA Recombination Organelle Organization Cellular Response To Stress Response To Ionizing Radiation Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Radiation Chromatin Organization Response To Stress Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Chromatin Modification Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Abiotic Stimulus Telomere Maintenance Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Cell Cycle Positive Regulation Of Cellular Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Protein Metabolic Process Cellular Metabolic Process Histone Modification Signal Transduction By P53 Class Mediator Response To Stimulus Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Cellular Response To Stimulus Cellular Protein Modification Process DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification DNA Damage Checkpoint Peptidyl-lysine Modification Cell Cycle Process Regulation Of Cellular Protein Metabolic Process DNA Replication Regulation Of Gene Expression Response To Gamma Radiation Negative Regulation Of Protein Metabolic Process Histone Acetylation Double-strand Break Repair Via Nonhomologous End Joining
Tagcloud ?		acetylation acetyltransferase appearance causes cd4 cd8 chip confirms demonstrates dp dynamic enhancer enhancers h3k14 haematopoietic hat hbo1 indistinguishable insufficiency localizes machinery mark progenitors promotes responsible serves tcrbeta thymocytes variegated
Tagcloud (Difference) ?		acetylation acetyltransferase appearance causes cd4 cd8 chip confirms demonstrates dp dynamic enhancer enhancers h3k14 haematopoietic hat hbo1 indistinguishable insufficiency localizes machinery mark progenitors promotes responsible serves tcrbeta thymocytes variegated
Tagcloud (Intersection) ?