TBC1D5 and AP2M1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TBC1D5	AP2M1
Gene Name		TBC1 domain family, member 5	adaptor-related protein complex 2, mu 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Autophagic Vacuole Endosome Membrane AP-2 Adaptor Complex Retromer Complex ULK1-ATG13-FIP200 Complex	Mitochondrion Lysosomal Membrane Cytosol Plasma Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Rab GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding	Signal Sequence Binding Transporter Activity Protein Binding Lipid Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Positive Regulation Of Receptor Internalization Autophagy Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Response To Starvation Regulation Of Cilium Assembly	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Membrane Organization Clathrin-mediated Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways			Retrograde neurotrophin signalling Axon guidance Gap junction degradation HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Formation of annular gap junctions Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression Gap junction trafficking Host Interactions of HIV factors Signaling by Ligand-Responsive EGFR Variants in Cancer The role of Nef in HIV-1 replication and disease pathogenesis NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Major depressive disorder ( 22472876)
Protein-Protein Interactions		7 interactors: AP2M1 ATXN1 EIF1AD GABARAPL1 GABARAPL2 MAP1LC3A VPS29	40 interactors: ADRA1B AP2B1 AQP4 ARRB2 ATXN1L CACNA1A CD22 CD3D CDK11B CORO7 CSNK2B CTLA4 DAB2 DCX DPPA2 DVL2 EHD2 FAM208A FURIN FXR2 GAK GRIN2B IKZF1 KCNJ11 LAMP1 LY9 MED4 MEGF10 NCOR2 NDRG1 RALBP1 RPL38 RRP12 RSPH14 RUNDC3A STON2 SYNJ1 TBC1D5 TGOLN2 ZBTB8A
Entrez ID		9779	1173
HPRD ID		10262	03014
Ensembl ID		ENSG00000131374	ENSG00000161203
Uniprot IDs		B9A6K1 Q92609	E9PFW3 Q96CW1
PDB IDs			1H6E
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Starvation Cellular Response To Nitrogen Starvation Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Membrane Organization Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Intracellular Transport Response To External Stimulus Establishment Of Localization In Cell Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cellular Localization Retrograde Transport, Endosome To Plasma Membrane Protein Transport Negative Regulation Of Protein Localization To Plasma Membrane Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Cellular Response To Stress	Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Cellular Process System Development Organ Development Endocytosis Signaling Regulation Of Endocytosis Cell Communication Multicellular Organismal Development Anatomical Structure Development Positive Regulation Of Endocytosis Positive Regulation Of Receptor-mediated Endocytosis Transport Protein Localization Developmental Process Positive Regulation Of Transport Cellular Response To Transforming Growth Factor Beta Stimulus Signal Transduction Response To Transforming Growth Factor Beta Cell Differentiation Synaptic Transmission Cell Development Establishment Of Protein Localization Chemotaxis Neurological System Process Regulation Of Signaling Cell-cell Signaling Cellular Response To Stimulus Nervous System Development Positive Regulation Of Receptor Internalization Regulation Of Androgen Receptor Signaling Pathway Establishment Of Localization In Cell Cellular Localization Single-organism Behavior Tube Development Behavioral Response To Pain Regulation Of Natural Killer Cell Mediated Cytotoxicity Cell Morphogenesis Involved In Differentiation Cell Proliferation Regulation Of Metabolic Process Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Membrane Potential Tissue Development Response To Stimulus Response To Estradiol Brain Development Protein Transport Positive Regulation Of Cellular Metabolic Process Regulation Of Receptor Internalization
Tagcloud ?		2z1 away barrel buds cerebellar cortex delineates fastigial flanking gabaergic inserted insertion insertional interneurons lacz landscape mapped mutagenesis neighbors nuclei pontine remote resembles satb1 somatosensory subdomain thymic tooth transgene	chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5
Tagcloud (Difference) ?		2z1 away barrel buds cerebellar cortex delineates fastigial flanking gabaergic inserted insertion insertional interneurons lacz landscape mapped mutagenesis neighbors nuclei pontine remote resembles satb1 somatosensory subdomain thymic tooth transgene	chemiluminescent chose escc ftl gearray gearrays gncpro guideline highlighted hla hspa8 immuno iran iranian locate mmp2 modalities modulatory northeast online prove rap1a tailed tp53i3 ube2l6 underexpressed verified verify xrcc5
Tagcloud (Intersection) ?