TBC1D5 and CHIA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TBC1D5	CHIA
Description		TBC1 domain family member 5	chitinase acidic
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GO Annotations	Cellular Component	Cytoplasm Endosome Autophagosome Golgi Apparatus Cytosol Endosome Membrane Membrane AP-2 Adaptor Complex Retromer Complex Cytoplasmic Vesicle Atg1/ULK1 Kinase Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding AP-2 Adaptor Complex Binding Protein-containing Complex Binding Retromer Complex Binding	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Chitinase Activity Protein Binding Chitin Binding Endochitinase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Kinase Binding
	Biological Process	Positive Regulation Of Receptor Internalization Autophagy Protein Transport Macroautophagy Retrograde Transport, Endosome To Golgi Response To Starvation Regulation Of Cilium Assembly	Polysaccharide Catabolic Process Immune System Process Production Of Molecular Mediator Involved In Inflammatory Response Carbohydrate Metabolic Process Chitin Metabolic Process Chitin Catabolic Process Apoptotic Process Inflammatory Response Positive Regulation Of Chemokine Production Polysaccharide Digestion
Pathways			Digestion of dietary carbohydrate
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Aspartate aminotransferase levels ( 33547301) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) General risk tolerance (MTAG) ( 30643258) Height ( 28552196) Language functional connectivity ( 34929384) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Parkinson's disease ( 32201043) Platelet count ( 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252 32888494) Schizophrenia ( 29483656 28991256 25056061) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: AP2M1 ATXN1 CHIA EIF1AD FBXL7 GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B UBC ZBTB25	3 interacting genes: COX20 RBBP8NL TBC1D5
Entrez ID		9779	27159
HPRD ID		10262	09355
Ensembl ID		ENSG00000131374	ENSG00000134216
Uniprot IDs		B9A6K1 Q92609	A8K3T7 Q1M0P3 Q1M0P4 Q2VT96 Q9BZP6
PDB IDs		5GTU	2YBT 2YBU 3FXY 3FY1 3RM4 3RM8 3RM9 3RME
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Autophagosome Assembly Autophagosome Organization Ubiquitin Protein Ligase Binding Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Autophagy Catabolic Process GABA Receptor Binding Cytoplasmic Vesicle Polysaccharide Catabolic Process Response To Nutrient Levels Beta-tubulin Binding Organelle Membrane Microtubule Binding Organelle Assembly Cytosol Polysaccharide Metabolic Process Endocytic Vesicle Membrane Protein-containing Complex Organization Microtubule Endochitinase Activity Signal Sequence Binding POZ Domain Binding Carbohydrate Catabolic Process Polysaccharide Digestion Cellular Response To Oxygen-glucose Deprivation Extrinsic Component Of Presynaptic Endocytic Zone Membrane Macromolecule Catabolic Process Chitin Metabolic Process Chitin Catabolic Process Chitinase Activity Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Recycling Chitin Binding Response To Iron(II) Ion Postsynaptic Neurotransmitter Receptor Internalization Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway	AP-2 Adaptor Complex Retromer Complex Binding AP-2 Adaptor Complex Binding Atg1/ULK1 Kinase Complex Retromer Complex Mitochondrial Cytochrome C Oxidase Assembly Respiratory Chain Complex IV Assembly Positive Regulation Of Receptor Internalization
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