PRPF38A and SRSF8

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PRPF38A	SRSF8
Description		pre-mRNA processing factor 38A	serine and arginine rich splicing factor 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	RNA Binding Protein Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS			Chronic widespread musculoskeletal pain ( 33331911)
Interacting Genes		29 interacting genes: AP2M1 APP CHERP CLK1 CLK2 CSNK2A1 DHX8 DVL3 GTF3C1 JMJD6 LUC7L2 MAPK6 POLA2 PPIG PRMT5 RBM39 RDX RNPS1 SDCBP SDCBP2 SRPK1 SRPK2 SRRM4 SRSF4 SRSF7 SRSF8 U2AF1 UBC ZCCHC10	24 interacting genes: APP CLK1 CLK2 CLK3 EIF4ENIF1 FOXP1 H19 KRTAP12-2 LUC7L LUC7L2 NXF1 PRPF38A PRPF6 RBM26 SNRNP48 SNRPA SREK1 SRPK1 SRPK2 SRSF3 ST13 TRA2B UBC WDR83
Entrez ID		84950	10929
HPRD ID		10972	04466
Ensembl ID		ENSG00000134748	ENSG00000263465
Uniprot IDs		Q8NAV1	Q9BRL6
PDB IDs		4RZ9 4RZA 5F5S 5O9Z 6AHD 7AAV 7ABF 7ABG 7ABI 8H6K 8Q7N 8QO9 8QPE 8QZS	2DNM
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing RNA Splicing Nuclear Speck MRNA Processing Regulation Of MRNA Metabolic Process MRNA Metabolic Process RNA Binding RNA Processing RNA Metabolic Process Nucleoplasm Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Nucleic Acid Binding Nucleus Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Protein Serine Kinase Activity Frizzled Binding Macromolecule Metabolic Process RS Domain Binding Protein Serine/threonine Kinase Activity MRNA Binding Protein Kinase Activity Protein Heterodimerization Activity Regulation Of Receptor Internalization Protein-RNA Complex Assembly Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Kinase Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of JNK Cascade Negative Regulation Of MRNA Metabolic Process Low-density Lipoprotein Particle Receptor Binding Protein Binding Positive Regulation Of Receptor Internalization Protein Serine/threonine/tyrosine Kinase Activity Neuron Maturation Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Viral Genome Replication Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	RNA Splicing Nuclear Speck MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Metabolic Process Spliceosomal Complex RNA Processing MRNA Binding U1 SnRNP Nucleus Protein Serine/threonine/tyrosine Kinase Activity RNA Metabolic Process MRNA Splicing, Via Spliceosome Protein-RNA Complex Assembly RNA Splicing, Via Transesterification Reactions Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleoplasm Spliceosomal Complex Assembly Regulation Of MRNA Metabolic Process Nucleic Acid Binding Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Nucleic Acid Metabolic Process U2-type Prespliceosome Pre-mRNA Binding Macromolecule Metabolic Process Protein Kinase Activity Protein Tyrosine Kinase Activity Nuclear Export Positive Regulation Of Viral Genome Replication MRNA Splice Site Recognition Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Kinase Activity Protein Phosphorylation Nucleobase-containing Compound Metabolic Process U4/U6 X U5 Tri-snRNP Complex Negative Regulation Of Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Phosphorylation Identical Protein Binding Negative Regulation Of Viral Genome Replication U2-type Precatalytic Spliceosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import
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