CD2 and MXD1

Number of citations of the paper that reports this interaction (PubMedID 11602341)
0

Data Source:
HPRD (in vitro, in vivo)

		CD2	MXD1
Description		CD2 molecule	MAX dimerization protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex	Chromatin Nucleus Nucleoplasm Mitochondrion Cytosol Mad-Max Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Membrane Raft Polarization Apoptotic Process Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Differentiation Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Carotid plaque burden (smoking interaction) ( 24954085) High light scatter reticulocyte count ( 27863252 32888494) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Red cell distribution width ( 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	18 interacting genes: AKT1 APP CD2 HDAC1 HDAC2 MAX MLX MYC MYCL MYCN PML PRAM1 RPS6KA1 RPS6KB1 SAP30 SIN3A SIN3B SMC3
Entrez ID		914	4084
HPRD ID		01750	02487
Ensembl ID		ENSG00000116824	ENSG00000059728
Uniprot IDs		P06729 Q53F96	B7ZLI7 Q05195
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I	1E91 1G1E 1NLW 1PD7 1S5Q
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation T Cell Costimulation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Gamma-delta T Cell Activation Plasma Membrane Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Leukocyte Activation Membrane Raft Negative Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Positive Regulation Of Cell Adhesion T Cell Activation Regulation Of Cell-cell Adhesion Natural Killer Cell Activation Fc Receptor Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Phospholipase Activator Activity Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Immune Response T Cell Receptor Binding Positive Regulation Of Leukocyte Differentiation Cell-cell Junction Extracellular Exosome Signaling Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process	Sin3-type Complex Nucleoplasm Chromatin Regulation Of Stem Cell Population Maintenance Negative Regulation Of Stem Cell Population Maintenance Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Biosynthetic Process Cellular Response To Catecholamine Stimulus Response To Growth Factor Positive Regulation Of RNA Metabolic Process Protein-containing Complex Myc-Max Complex Negative Regulation Of Cell Migration Response To Catecholamine Protein Dimerization Activity Regulation Of Programmed Cell Death Negative Regulation Of Cell Motility Negative Regulation Of Gene Expression Negative Regulation Of Locomotion Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Negative Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Lysine Delactylase Activity
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