CD2 and CD53

Number of citations of the paper that reports this interaction (PMID 1346273)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD2	CD53
Gene Name		CD2 molecule	CD53 molecule
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane	Immunological Synapse Plasma Membrane Cell-cell Junction Cell Surface Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion	Signal Transduction Positive Regulation Of Myoblast Fusion
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Alpha-D-Mannose
Diseases
GWAS			Cytomegalovirus antibody response ( 21993531) Obesity-related traits ( 23251661)
Protein-Protein Interactions		19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1	6 interactors: CD2 CD4 CD9 GGT1 IL2 IL4
Entrez ID		914	963
HPRD ID		01750	01054
Ensembl ID		ENSG00000116824	ENSG00000143119
Uniprot IDs		P06729 Q53F96	B4DQB5 P19397
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation	Cell Activation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cytokine Production Regulation Of Cell-cell Adhesion Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Lymphocyte Activation Lymphocyte Activation Regulation Of Isotype Switching To IgG Isotypes Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of T Cell Differentiation Regulation Of Immune System Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Differentiation Regulation Of Lymphocyte Differentiation Regulation Of Cell Adhesion Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Isotype Switching Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Isotype Switching Positive Regulation Of Immune System Process Regulation Of Inflammatory Response Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Activated T Cell Proliferation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation T Cell Selection Leukocyte Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interferon-gamma Production Positive Regulation Of Cell Adhesion Regulation Of B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Natural Killer Cell Activation
Tagcloud ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Difference) ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	bioinformatics coeruleus ctss cx3cr1 degs downloaded encyclopedia enriched excision genomes glycan gse34516 hub idiopathic igsf6 ipd kyoto laptm5 mismatch mortem omnibus ontology paired ppi ptprc slc5a7 spliceosome splicing transesterification
Tagcloud (Intersection) ?