CD2 and LYAR

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CD2	LYAR
Gene Name		CD2 molecule	Ly1 antibody reactive
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Anchored Component Of Plasma Membrane	Nucleus Nucleolus
	Molecular Function	Receptor Activity Receptor Binding Protein Binding Protein Homodimerization Activity	Protein Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Blood Coagulation Single Organismal Cell-cell Adhesion Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Positive Regulation Of Interferon-gamma Secretion Positive Regulation Of Interleukin-8 Secretion
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Alpha-D-Mannose
Diseases
GWAS
Protein-Protein Interactions		19 interactors: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1	11 interactors: ADSSL1 BEND7 CD2 FGF18 PHF20L1 PRKRA SDCBP2 TERF1 TERF2 ZBTB16 ZHX1
Entrez ID		914	55646
HPRD ID		01750	10064
Ensembl ID		ENSG00000116824	ENSG00000145220
Uniprot IDs		P06729 Q53F96	Q9NX58
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation T Cell Costimulation Positive Regulation Of Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Regulation Of Cell Activation Immune System Process Regulation Of Defense Response To Virus By Virus Regulation Of Cell Adhesion T Cell Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Defense Response Regulation Of Defense Response To Virus Innate Immune Response Cell Migration Locomotion Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Cell Motility Signal Transduction Cellular Response To Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Activation Response To Wounding Signaling Lymphocyte Activation Response To Stimulus Cell Communication Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Positive Regulation Of Gamma-delta T Cell Differentiation Leukocyte Activation Leukocyte Migration Regulation Of Immune Response Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Single Organismal Cell-cell Adhesion Response To Stress Viral Process T Cell Aggregation T Cell Activation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Aggregation	Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Replicative Cell Aging Regulation Of Nuclear Cell Cycle DNA Replication Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance RNA-dependent DNA Replication Positive Regulation Of Chondrocyte Differentiation Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Cartilage Development Negative Regulation Of DNA Replication Regulation Of Chondrocyte Differentiation Cell Aging Telomere Maintenance Positive Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of Chromosome Organization Regulation Of Cartilage Development Immune System Process Negative Regulation Of DNA Metabolic Process Developmental Process Regulation Of T Cell Differentiation Skeletal System Development Regulation Of DNA Replication Negative Regulation Of Biosynthetic Process Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Membrane Raft Polarization 'de Novo' AMP Biosynthetic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Interferon-gamma Secretion Protection From Non-homologous End Joining At Telomere Regulation Of Lymphocyte Differentiation Membrane Raft Localization Telomere Capping Positive Regulation Of NK T Cell Differentiation Protein Localization To Chromosome, Telomeric Region AMP Biosynthetic Process Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Telomere Maintenance Via Telomerase Regulation Of Myeloid Dendritic Cell Activation Cartilage Development Nucleobase-containing Compound Metabolic Process Aspartate Metabolic Process Regulation Of Chromosome Organization Heterocycle Metabolic Process
Tagcloud ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	34a abcf2 adhesions alg13 bioinformatics chance ctcf fak held kaplan ki67 meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr
Tagcloud (Difference) ?		2c4 assign b10 b3 b9 complementation crossed crosses crossing facs gbp guanylate hlas hybrids ifn jak1 oas oligoadenylate pairwise permitted responsiveness restore rounds submitted synthetase u3 u4 unresponsive unresponsiveness	34a abcf2 adhesions alg13 bioinformatics chance ctcf fak held kaplan ki67 meier michigan mir nbl neuroblastoma originates proteome proteomics searches seed sh shep sy5y sympathetic tetracycline tgm2 timm13 utr
Tagcloud (Intersection) ?