CD2 and LINC00311

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CD2	LINC00311
Description		CD2 molecule	long intergenic non-protein coding RNA 311
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Golgi Apparatus Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Membrane Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process	Membrane Raft Polarization Apoptotic Process Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Natural Killer Cell Mediated Cytotoxicity Regulation Of T Cell Differentiation Cell-cell Adhesion
Pathways		Cell surface interactions at the vascular wall
Drugs		Alefacept Siplizumab
Diseases
GWAS		Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)	Systolic blood pressure ( 30224653) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC	1 interacting genes: CD2
Entrez ID		914	197196
HPRD ID		01750	14484
Ensembl ID		ENSG00000116824	ENSG00000179219
Uniprot IDs		P06729 Q53F96
PDB IDs		1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?		T Cell Receptor Signaling Pathway Immune System Process Regulation Of Immune System Process Positive Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation T Cell Costimulation Positive Regulation Of Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Activation Of Immune Response Positive Regulation Of T Cell Activation Positive Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Activation Gamma-delta T Cell Activation Plasma Membrane Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Immune Response-activating Signaling Pathway Leukocyte Activation Membrane Raft Negative Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation CD8 Receptor Binding Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Activation Cell Activation Positive Regulation Of Cell Adhesion T Cell Activation Regulation Of Cell-cell Adhesion Natural Killer Cell Activation Fc Receptor Signaling Pathway CD4 Receptor Binding Positive Regulation Of Gamma-delta T Cell Differentiation Phospholipase Activator Activity Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Immune Response T Cell Receptor Binding Positive Regulation Of Leukocyte Differentiation Cell-cell Junction Extracellular Exosome Signaling Receptor Binding Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Multicellular Organismal Process	Membrane Raft Distribution Membrane Raft Polarization Membrane Raft Localization Positive Regulation Of Myeloid Dendritic Cell Activation Determination Of Pancreatic Left/right Asymmetry Determination Of Liver Left/right Asymmetry Determination Of Digestive Tract Left/right Asymmetry Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Left/right Pattern Formation Inner Dynein Arm Assembly Regulation Of Cilium Beat Frequency Outer Dynein Arm Assembly Dynein Complex Binding Membrane Raft Organization Heterotypic Cell-cell Adhesion Regulation Of Cilium Movement Axonemal Dynein Complex Assembly Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Motile Cilium Assembly Epithelial Cilium Movement Involved In Extracellular Fluid Movement Natural Killer Cell Activation Axoneme Assembly Extracellular Transport Regulation Of Microtubule-based Movement Receptor Tyrosine Kinase Binding Positive Regulation Of Interleukin-8 Production Heart Looping Embryonic Heart Tube Morphogenesis Positive Regulation Of Type II Interferon Production Leukocyte Mediated Cytotoxicity Regulation Of Interleukin-8 Production Determination Of Bilateral Symmetry Microtubule Bundle Formation Determination Of Left/right Symmetry
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