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MCM4 and ORC3
Number of citations of the paper that reports this interaction (PMID
12614612
)
16
Data Source:
BioGRID
(two hybrid)
MCM4
ORC3
Gene Name
minichromosome maintenance complex component 4
origin recognition complex, subunit 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Membrane
MCM Complex
Origin Recognition Complex
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Molecular Function
Single-stranded DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
DNA Replication Origin Binding
Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Replication
Neural Precursor Cell Proliferation
Pathways
Synthesis of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
DNA Replication Pre-Initiation
M/G1 Transition
Regulation of DNA replication
Activation of the pre-replicative complex
Orc1 removal from chromatin
S Phase
DNA strand elongation
Cell Cycle, Mitotic
Assembly of the pre-replicative complex
Orc1 removal from chromatin
G1/S Transition
Activation of ATR in response to replication stress
Cell Cycle Checkpoints
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
Unwinding of DNA
G2/M Checkpoints
Activation of the pre-replicative complex
Activation of the pre-replicative complex
Orc1 removal from chromatin
Assembly of the pre-replicative complex
Activation of ATR in response to replication stress
G1/S Transition
Assembly of the ORC complex at the origin of replication
Removal of licensing factors from origins
Mitotic G1-G1/S phases
Switching of origins to a post-replicative state
E2F mediated regulation of DNA replication
Synthesis of DNA
DNA Replication Pre-Initiation
Regulation of DNA replication
M/G1 Transition
S Phase
CDC6 association with the ORC:origin complex
Cell Cycle, Mitotic
Orc1 removal from chromatin
E2F-enabled inhibition of pre-replication complex formation
Cell Cycle Checkpoints
Association of licensing factors with the pre-replicative complex
CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Obesity-related traits (
23251661
)
Protein-Protein Interactions
24 interactors:
CCNA1
CDC5L
CDC7
CDK1
CDK2
CDT1
DBF4
LIG4
MCM2
MCM3
MCM6
MCM7
MCM8
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
RPA1
RPA2
SSRP1
SUPT16H
TLX2
18 interactors:
APP
CCNE2
CDC45
CDC6
CDK4
DBF4
HIST3H3
HIST4H4
MCM10
MCM4
MCM5
MCM7
ORC1
ORC2
ORC4
ORC5
ORC6
TERF2
Entrez ID
4173
23595
HPRD ID
09094
05398
Ensembl ID
ENSG00000104738
ENSG00000135336
Uniprot IDs
B3KMX0
B4DLA6
P33991
Q9UBD5
PDB IDs
Enriched GO Terms of Interacting Partners
?
DNA Replication
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Metabolic Process
DNA-dependent DNA Replication
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Cell Cycle Process
Cell Cycle
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Biosynthetic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Response To DNA Damage Stimulus
DNA Repair
Chromosome Organization
Cellular Response To Stress
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Cellular Metabolic Process
DNA Unwinding Involved In DNA Replication
Double-strand Break Repair
Nucleotide-excision Repair, DNA Gap Filling
DNA Duplex Unwinding
DNA Geometric Change
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Cell Cycle Checkpoint
Regulation Of Cell Cycle Phase Transition
DNA Recombination
DNA Conformation Change
Regulation Of Cell Cycle Process
Regulation Of DNA Replication
DNA Recombinase Assembly
Organelle Organization
DNA Damage Checkpoint
Regulation Of DNA-dependent DNA Replication Initiation
Regulation Of Cell Cycle
Metabolic Process
Response To Stress
Positive Regulation Of DNA Replication
Regulation Of Nuclear Cell Cycle DNA Replication
Regulation Of Mitotic Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
DNA Replication
DNA Replication Initiation
Mitotic Cell Cycle
DNA Metabolic Process
DNA-dependent DNA Replication
Mitotic Cell Cycle Process
Cell Cycle
Cell Cycle Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
DNA Strand Elongation Involved In DNA Replication
Cellular Macromolecule Biosynthetic Process
DNA Strand Elongation
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Phase Transition
Cellular Metabolic Process
DNA Duplex Unwinding
Biosynthetic Process
DNA Geometric Change
Chromosome Organization
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
DNA Conformation Change
Positive Regulation Of Mitotic Cell Cycle
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Process
Regulation Of Cell Cycle Phase Transition
Telomere Maintenance
DNA Replication Checkpoint
DNA Unwinding Involved In DNA Replication
Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Metabolic Process
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Cell Cycle G1/S Phase Transition
Organelle Organization
Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of DNA Replication
Cell Cycle Checkpoint
Tagcloud
?
adh8l
alveolus
bmp16
clu1
clu2
coho
col1a1
col1a2
cyp19a1a
dcn
ddit4l
droplet
fishes
fn1
fsh
fshr
inha
ivns1abpa
maturing
oogenesis
perinucleolus
pim1
salmon
smad5l
steroidogenesis
suite
vitellogenic
wapl
wt2l
Tagcloud (Difference)
?
adh8l
alveolus
bmp16
clu1
clu2
coho
col1a1
col1a2
cyp19a1a
dcn
ddit4l
droplet
fishes
fn1
fsh
fshr
inha
ivns1abpa
maturing
oogenesis
perinucleolus
pim1
salmon
smad5l
steroidogenesis
suite
vitellogenic
wapl
wt2l
Tagcloud (Intersection)
?