MCM4 and ESCO2

Number of citations of the paper that reports this interaction (PubMedID 30100344)
0

Data Source:
BioGRID (two hybrid)

		MCM4	ESCO2
Description		minichromosome maintenance complex component 4	establishment of sister chromatid cohesion N-acetyltransferase 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Chromatin XY Body Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Golgi Apparatus Chromocenter Cell Junction Site Of Double-strand Break
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Protein Binding N-acetyltransferase Activity Zinc Ion Binding Acetyltransferase Activity Transferase Activity Acyltransferase Activity Metal Ion Binding Protein-lysine-acetyltransferase Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Chromosome Segregation Sister Chromatid Cohesion Mitotic Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Establishment of Sister Chromatid Cohesion
Drugs
Diseases			ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		28 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 CEBPA DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SSRP1 SUMO2 SUPT16H TLX2 UBE3A	12 interacting genes: FXR1 GOLGA2 MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA PICK1 RABEP1 SMC3
Entrez ID		4173	157570
HPRD ID		09094	18564
Ensembl ID		ENSG00000104738	ENSG00000171320
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q56NI9
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Replication Nucleic Acid Metabolic Process Origin Recognition Complex Chromosome, Telomeric Region Nucleobase-containing Compound Metabolic Process MCM Complex Nucleoplasm Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding DNA Repair Nucleus Macromolecule Metabolic Process DNA Damage Response Regulation Of DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome CMG Complex Double-strand Break Repair Cellular Response To Stress Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated DNA Replication DNA Binding Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Recombination Recombinational Repair G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin Binding ATP Binding Single-stranded DNA Binding Regulation Of Nuclear Cell Cycle DNA Replication DNA-templated DNA Replication Helicase Activity Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Primary Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Nucleotide Binding Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex	MCM Complex CMG Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication DNA Replication Initiation Single-stranded DNA Binding Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Repair DNA Replication Single-stranded DNA Helicase Activity Chromosome, Telomeric Region Double-strand Break Repair DNA Metabolic Process DNA Recombination DNA Damage Response DNA Helicase Activity Regulation Of DNA Metabolic Process Helicase Activity Cellular Response To Stress ATP Hydrolysis Activity DNA Strand Elongation Involved In DNA Replication Chromosome DNA Strand Elongation Mitotic DNA Replication Initiation Nucleic Acid Metabolic Process Response To Stress 3'-5' DNA Helicase Activity DNA Replication Origin Binding Nucleobase-containing Compound Metabolic Process Nuclear Replication Fork Macromolecule Metabolic Process ATP Binding DNA Binding Replication Fork Processing Mitotic Spindle Assembly Nucleotide Binding PCNA Complex Replisome Membraneless Organelle Assembly Cellular Response To Xenobiotic Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Receptor Internalization PCNA-p21 Complex DNA Polymerase Processivity Factor Activity Purine-specific Mismatch Base Pair DNA N-glycosylase Activity Nucleoplasm Mitotic Spindle Organization
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