MCM4 and SUPT16H

Number of citations of the paper that reports this interaction (PubMedID 16902406)
38

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		MCM4	SUPT16H
Description		minichromosome maintenance complex component 4	SPT16 homolog, facilitates chromatin remodeling subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Nucleus Nucleoplasm Chromosome Transcription Elongation Factor Complex FACT Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	RNA Binding Protein Binding Nucleosome Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Mitotic DNA Replication Initiation	DNA Replication DNA Repair Nucleosome Assembly Nucleosome Disassembly Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II DNA Damage Response Positive Regulation Of DNA-templated Transcription, Elongation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Eosinophil percentage of white cells ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 27863252) Reticulocyte count ( 32888494)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		28 interacting genes: CCNA1 CDC5L CDC7 CDK1 CDK2 CDT1 CEBPA DBF4 EP300 ESCO2 LIG4 MCM2 MCM3 MCM6 MCM7 MCM8 MCMBP ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 SSRP1 SUMO2 SUPT16H TLX2 UBE3A	15 interacting genes: CCT6A GTF2E2 H2AC13 H3-3A H3C1 H4C1 MCM3 MCM4 NEK9 PARP1 RNF10 SREK1 SRPK2 SUMO2 USP7
Entrez ID		4173	11198
HPRD ID		09094	16088
Ensembl ID		ENSG00000104738	ENSG00000092201
Uniprot IDs		B3KMX0 B4DLA6 P33991	Q9Y5B9
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	4Z2M 4Z2N 5E5B 5UMT 5UMU 5XM2 6UPK 6UPL 8I17 8YJF 8YJM 9EH2
Enriched GO Terms of Interacting Partners?		DNA Replication DNA Metabolic Process DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex Regulation Of DNA Replication Nucleic Acid Metabolic Process Origin Recognition Complex Chromosome, Telomeric Region Nucleobase-containing Compound Metabolic Process MCM Complex Nucleoplasm Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding DNA Repair Nucleus Macromolecule Metabolic Process DNA Damage Response Regulation Of DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome CMG Complex Double-strand Break Repair Cellular Response To Stress Positive Regulation Of DNA Replication Positive Regulation Of DNA-templated DNA Replication DNA Binding Single-stranded DNA Helicase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Via Homologous Recombination DNA Recombination Recombinational Repair G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin Binding ATP Binding Single-stranded DNA Binding Regulation Of Nuclear Cell Cycle DNA Replication DNA-templated DNA Replication Helicase Activity Cyclin A1-CDK1 Complex Cyclin A1-CDK2 Complex Regulation Of Primary Metabolic Process Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Nucleotide Binding Mitotic DNA Replication Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex	Chromosome Chromosome, Telomeric Region Chromatin Remodeling Structural Constituent Of Chromatin Chromatin Organization Telomere Organization Nucleus Nucleosome Mitotic DNA Replication Initiation Regulation Of Establishment Of Protein Localization To Telomere Nucleoplasm Regulation Of Establishment Of Protein Localization To Chromosome RNA Binding DNA Binding CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization DNA Strand Elongation Involved In DNA Replication Regulation Of DNA-templated DNA Replication Initiation Epigenetic Regulation Of Gene Expression Regulation Of Telomere Maintenance Nucleosome Assembly Single-stranded DNA Helicase Activity DNA Strand Elongation Nucleic Acid Metabolic Process Chromosome Organization Protein Heterodimerization Activity Nucleosome Organization Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication Initiation Regulation Of Macromolecule Metabolic Process Protein-containing Complex Negative Regulation Of Gene Expression, Epigenetic Protein-DNA Complex Assembly NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity Macromolecule Metabolic Process NAD+-protein-histidine ADP-ribosyltransferase Activity NAD+-protein-tyrosine ADP-ribosyltransferase Activity Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Protein Localization To Chromatin DNA Repair Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process DNA Recombination
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